Adult-onset perinuclear antineutrophil cytoplasmic antibody-positive Henoch-Schönlein purpura in diabetic nephropathy

Shyh Ming Hong, Yung Chang Chen, Swei Hsueh, Chang Chyi Jenq, Ji Tseng Fang, Chih Wei Yang, Ya Chung Tian*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Adult-onset Henoch-Schönlein purpura (HSP) is a rare systemic vasculitis characterized by a leukocytoclastic vasculitis of small vessels with the deposition of IgA immune complexes involving skin, gastrointestinal tract, joints and kidneys. Antineutrophil cytoplasmic antibody (ANCA) detected by indirect immunofluorescence assay is commonly found in other vasculitic disorders but rarely discovered in HSP patients. ANCA with perinuclear pattern has hardly ever reported in HSP patients. The diagnostic importance of ANCA still remains controversial. In addition, the simultaneous presence of diabetic nephropathy and HSP is uncommon. We present a case of an adult patient with diabetic nephropathy and superimposed HSP, which resulted in acute renal failure. Perinuclear-pattern ANCA was detected in the acute phase of HSP but disappeared when the disease resolved. Further, we have reviewed ANCA-positive HSP in this article.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalJournal of Nephrology
Volume22
Issue number1
StatePublished - 2009

Keywords

  • Acute renal failure
  • Antineutrophic cytoplasmic antibody
  • Diabetic nephropathy
  • Henoch-Schönlein purpura
  • Myeloperoxidase

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