TY - JOUR
T1 - Advanced technologies for studying circulating tumor cells at the protein level
AU - Chan, Charles Ming Lok
AU - Au, Thomas Chi Chuen
AU - Chan, Anthony Tak Cheung
AU - Ma, Brigette Buig Yue
AU - Tsui, Nancy Bo Yin
AU - Ng, Simon Siu Man
AU - Hui, Edwin Pun
AU - Chan, Lawrence Wing Chi
AU - Ho, Wing Shan
AU - Yung, Benjamin Yat Ming
AU - Wong, Sze Chuen Cesar
PY - 2013
Y1 - 2013
N2 - Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biological characteristics of CTCs for development of novel treatment modalities to minimize metastasis-associated cancer deaths. In recent years, rapid developments in technologies for the study of CTCs have taken place. We now have a variety of tools for the isolation and examination of CTCs which were not available before. This review introduces some commonly used protein markers in CTC investigations and summarizes a few advanced technologies which have been successfully applied for studying CTC biology at the protein level.
AB - Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biological characteristics of CTCs for development of novel treatment modalities to minimize metastasis-associated cancer deaths. In recent years, rapid developments in technologies for the study of CTCs have taken place. We now have a variety of tools for the isolation and examination of CTCs which were not available before. This review introduces some commonly used protein markers in CTC investigations and summarizes a few advanced technologies which have been successfully applied for studying CTC biology at the protein level.
KW - CTC-chip
KW - Cellsearch
KW - Circulating tumor cells
KW - EPISPOT
KW - Immunomagnetic bead
KW - Proteomic
UR - https://www.scopus.com/pages/publications/84887967740
U2 - 10.1586/14789450.2013.858021
DO - 10.1586/14789450.2013.858021
M3 - 文献综述
C2 - 24206230
AN - SCOPUS:84887967740
SN - 1478-9450
VL - 10
SP - 579
EP - 589
JO - Expert Review of Proteomics
JF - Expert Review of Proteomics
IS - 6
ER -
