Adverse medication reactions

Roni P. Dodiuk-Gad; Wen Hung Chung; Neil H. Shear

doi:10.1007/978-3-319-29785-9_25

Adverse medication reactions

Roni P. Dodiuk-Gad, Wen Hung Chung, Neil H. Shear^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Cutaneous adverse drug reactions (ADRs) are among the most frequent adverse reactions in patients receiving drug therapy. They have a broad spectrum of clinical manifestations, are caused by various drugs, and result from different pathophysiological mechanisms. Hence, their diagnosis and management is challenging. Severe cutaneous ADRs comprise a group of diseases with major morbidity and mortality, reaching 30 % mortality rate in cases of Toxic Epidermal Necrolysis. This chapter covers the terminology, epidemiology, pathogenesis and classification of cutaneous ADR, describes the severe cutaneous ADRs and the clinical and laboratory approach to the patient with cutaneous ADR and presents the translation of laboratorybased discoveries on the genetic predisposition and pathogenesis of cutaneous ADRs to clinical management guidelines.

Original language	English
Title of host publication	Clinical and Basic Immunodermatology
Subtitle of host publication	Second Edition
Publisher	Springer International Publishing
Pages	439-467
Number of pages	29
ISBN (Electronic)	9783319297859
ISBN (Print)	9783319297835
DOIs	https://doi.org/10.1007/978-3-319-29785-9_25
State	Published - 24 04 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2017. All rights reserved.

Keywords

Classification
Clinical approach
Cutaneous adverse drug reactions
Human leukocyte antigen (HLA)
Laboratory tests
Pathogenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-29785-9_25

Cite this

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AU - Chung, Wen Hung

AU - Shear, Neil H.

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KW - Clinical approach

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KW - Human leukocyte antigen (HLA)

KW - Laboratory tests

KW - Pathogenesis

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Adverse medication reactions

Abstract

Bibliographical note

Keywords

UN SDGs

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