TY - JOUR
T1 - Age‐specific prevalence and significance of hepatitis B e antigen and antibody in chronic hepatitis B virus infection in taiwan
T2 - A comparison among asymptomatic carriers, Chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma
AU - Liaw, Yun‐Fan ‐F
AU - Chu, Chia‐Ming ‐M
AU - Lin, Deng‐Yn ‐Y
AU - Sheen, I‐Shyan ‐S
AU - Yang, Chaur‐Young ‐Y
AU - Huang, Miau‐Ju ‐J
PY - 1984
Y1 - 1984
N2 - The age‐specific prevalence of hepatitis B e antigen (HBeAg) and its antibody (anti‐HBe) were studied by radioimmunoassay, and compared in a large series of patients with chronic hepatitis B virus (HBV) infection, including 268 asymptomatic carriers. 389 chronic hepatitis, 114 liver cirrhosis, and 278 hepatocellular carcinoma (HCC). The prevalence of HBeAg/anti‐HBe in asymptomatic carriers and patients with chronic hepatitis correlated closely with age as HBeAg prevalence decreased and anti‐HBe prevalence increased with increasing age (P < 0.0005), and is probably due to high infection rate at young age in Taiwan. The prevalence of HBeAg in patients with both cirrhosis and HCC are much significantly lower and had no correlation with age. Two peaks of age‐specific prevalence of HBeAg and anti‐HBe were observed in patients with HCC, implicating two patterns of HBV infection in these patients. The difference in the prevalence of HBeAg and anti‐HBe might indicate that asymptomatic carriers, chronic hepatitis, liver cirrhosis, and HCC are sequential sequelae of HBV infection.
AB - The age‐specific prevalence of hepatitis B e antigen (HBeAg) and its antibody (anti‐HBe) were studied by radioimmunoassay, and compared in a large series of patients with chronic hepatitis B virus (HBV) infection, including 268 asymptomatic carriers. 389 chronic hepatitis, 114 liver cirrhosis, and 278 hepatocellular carcinoma (HCC). The prevalence of HBeAg/anti‐HBe in asymptomatic carriers and patients with chronic hepatitis correlated closely with age as HBeAg prevalence decreased and anti‐HBe prevalence increased with increasing age (P < 0.0005), and is probably due to high infection rate at young age in Taiwan. The prevalence of HBeAg in patients with both cirrhosis and HCC are much significantly lower and had no correlation with age. Two peaks of age‐specific prevalence of HBeAg and anti‐HBe were observed in patients with HCC, implicating two patterns of HBV infection in these patients. The difference in the prevalence of HBeAg and anti‐HBe might indicate that asymptomatic carriers, chronic hepatitis, liver cirrhosis, and HCC are sequential sequelae of HBV infection.
KW - asymptomatic carriers
KW - chronic hepatitis B
KW - hepatitis B e antigen/antibody
KW - hepatitis B virus (HBV)
KW - hepatocellular carcinoma
KW - liver cirrhosis
UR - https://www.scopus.com/pages/publications/0021277726
U2 - 10.1002/jmv.1890130410
DO - 10.1002/jmv.1890130410
M3 - 文章
C2 - 6330293
AN - SCOPUS:0021277726
SN - 0146-6615
VL - 13
SP - 385
EP - 391
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 4
ER -
