Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila

Jui Shu Chang, Hsin Ping Liu, Jack Cheng, Chao Jung Chen, Su Lun Hwang, Chi Chuan Tseng, Lee Fen Hsu*, Wei Yong Lin

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations

Abstract

In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory. In previous studies, A. julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia. However, whether A. julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear. We utilized the sleep-deprived Drosophila model and olfactory associative learning-memory assay to test the effects of A. julibrissin on sleep-deprivation induced memory loss. We found that A. julibrissin ameliorated 3-hour memory but not 1-hour memory or instant learning. The findings might be applied to an anticipated short-term sleep disturbance.

Original languageEnglish
Article number7395962
JournalEvidence-based Complementary and Alternative Medicine
Volume2019
DOIs
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Jui-Shu Chang et al.

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