Abstract
Multiple primary tumors (MPT), especially in the zygotes for oral cavity (P ¼ 0.013) and oropharyngeal hypopharynx and esophagus, are challenging in cancers (P ¼ 0.012). For ADH1B, the number of 1 patients with head and neck cancer (HNC). Alcohol allele carriers is significantly higher than that of 22 and alcohol-metabolizing genes were reported to be homozygotes for oropharyngeal (P ¼ 0.017) and related to upper digestive tract cancers. Here, we hypopharyngeal cancers (P < 0.001). ADH1C (rs698) investigated whether the genotypes of alcohol-SNPs are not significantly associated with tumor metabolizing enzymes (ADH1B, ADH1C, and subsites (all P > 0.05). Polymorphisms in ALDH2 ALDH2) affected patients' susceptibility to develop-(2 allele carriers) and ADH1B (1 allele carriers) ing MPTs. We recruited 659 male patients with HNC significantly increase the risk of developing MPTs between March 1996 and February 2017. Age- and in the upper digestive tract [P < 0.001, OR (95% gender-matched controls were also recruited. A total confidence interval (CI): 5.186 (2.444–11.004) and of 164 patients with HNC were identified to have P < 0.05, OR (95% CI): 2.093 (1.149–3.812), second or third malignancies. The single-nucleotide respectively]. ALDH2 (rs671) 2 and ADH1B polymorphisms in ADH1B (rs1229984), ADH1C (rs1229984) 1 allele carriers were shown to develop (rs698), and ALDH2 (rs671) were analyzed by Taq-MPTs in the upper digestive tract. Genetic informa-Man assays. The prevalence of ALDH2 2 allele cartion may be used to identify high-risk patients for the riers is significantly higher than that of 11 homo-development of MPTs.
Original language | English |
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Pages (from-to) | 247-254 |
Number of pages | 8 |
Journal | Cancer Prevention Research |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - 01 04 2019 |
Bibliographical note
Publisher Copyright:© 2019 American Association for Cancer Research.