Alcohol-metabolizing enzymes' gene polymorphisms and susceptibility to multiple head and neck cancers

Huei Tzu Chien, Chi Kuang Young, Tzu Ping Chen, Chun Ta Liao, Hung Ming Wang, Sou De Cheng, Shiang Fu Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Multiple primary tumors (MPT), especially in the zygotes for oral cavity (P ¼ 0.013) and oropharyngeal hypopharynx and esophagus, are challenging in cancers (P ¼ 0.012). For ADH1B, the number of 1 patients with head and neck cancer (HNC). Alcohol allele carriers is significantly higher than that of 22 and alcohol-metabolizing genes were reported to be homozygotes for oropharyngeal (P ¼ 0.017) and related to upper digestive tract cancers. Here, we hypopharyngeal cancers (P < 0.001). ADH1C (rs698) investigated whether the genotypes of alcohol-SNPs are not significantly associated with tumor metabolizing enzymes (ADH1B, ADH1C, and subsites (all P > 0.05). Polymorphisms in ALDH2 ALDH2) affected patients' susceptibility to develop-(2 allele carriers) and ADH1B (1 allele carriers) ing MPTs. We recruited 659 male patients with HNC significantly increase the risk of developing MPTs between March 1996 and February 2017. Age- and in the upper digestive tract [P < 0.001, OR (95% gender-matched controls were also recruited. A total confidence interval (CI): 5.186 (2.444–11.004) and of 164 patients with HNC were identified to have P < 0.05, OR (95% CI): 2.093 (1.149–3.812), second or third malignancies. The single-nucleotide respectively]. ALDH2 (rs671) 2 and ADH1B polymorphisms in ADH1B (rs1229984), ADH1C (rs1229984) 1 allele carriers were shown to develop (rs698), and ALDH2 (rs671) were analyzed by Taq-MPTs in the upper digestive tract. Genetic informa-Man assays. The prevalence of ALDH2 2 allele cartion may be used to identify high-risk patients for the riers is significantly higher than that of 11 homo-development of MPTs.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalCancer Prevention Research
Volume12
Issue number4
DOIs
StatePublished - 01 04 2019

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Publisher Copyright:
© 2019 American Association for Cancer Research.

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