Aldosterone-to-renin ratio (ARR) as a screening tool for primary aldosteronism (PA)

Chia Hung Lin; Ching Han Lin; Mu Chi Chung; Chi Sheng Hung; Fen Yu Tseng; Leay Kiaw Er; Charles Jia-Yin Hou; Yen Hung Lin; Vin Cent Wu; Hao Min Cheng; Hsien Li Kao; Kwan Dun Wu; Tai Shuan Lai

doi:10.1016/j.jfma.2023.04.019

Aldosterone-to-renin ratio (ARR) as a screening tool for primary aldosteronism (PA)

Chia Hung Lin, Ching Han Lin, Mu Chi Chung, Chi Sheng Hung, Fen Yu Tseng, Leay Kiaw Er, Charles Jia-Yin Hou, Yen Hung Lin, Vin Cent Wu, Hao Min Cheng, Hsien Li Kao, Kwan Dun Wu, Tai Shuan Lai^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The aldosterone-to-renin ratio (ARR) is the standard screening test for primary aldosteronism (PA). Because of the poor reproducibility of the ARR, repeat testing is recommended if the result is not compatible with the clinical condition. Various methods to measure renin are used in different hospitals in Taiwan, and the ARR cutoff values also differ among laboratories. The Task Force of Taiwan PA recommend using plasma renin activity (PRA) to calculate ARR instead of direct renin concentration (DRC) unless PRA is unavailable, because PRA is widely used in international guidelines and most studies.

Original language	English
Pages (from-to)	S98-S103
Journal	Journal of the Formosan Medical Association
Volume	123 Suppl 2
DOIs	https://doi.org/10.1016/j.jfma.2023.04.019
State	Published - 03 2024
Externally published	Yes

Bibliographical note

Keywords

Aldosterone
Aldosterone-to-renin ratio
Primary aldosteronism
Renin
Screening
Reproducibility of Results
Hospitals
Humans
Hyperaldosteronism/diagnosis
Hypertension/etiology

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10.1016/j.jfma.2023.04.019

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title = "Aldosterone-to-renin ratio (ARR) as a screening tool for primary aldosteronism (PA)",

abstract = "The aldosterone-to-renin ratio (ARR) is the standard screening test for primary aldosteronism (PA). Because of the poor reproducibility of the ARR, repeat testing is recommended if the result is not compatible with the clinical condition. Various methods to measure renin are used in different hospitals in Taiwan, and the ARR cutoff values also differ among laboratories. The Task Force of Taiwan PA recommend using plasma renin activity (PRA) to calculate ARR instead of direct renin concentration (DRC) unless PRA is unavailable, because PRA is widely used in international guidelines and most studies.",

keywords = "Aldosterone, Aldosterone-to-renin ratio, Primary aldosteronism, Renin, Screening, Reproducibility of Results, Hospitals, Humans, Hyperaldosteronism/diagnosis, Hypertension/etiology",

author = "Lin, {Chia Hung} and Lin, {Ching Han} and Chung, {Mu Chi} and Hung, {Chi Sheng} and Tseng, {Fen Yu} and Er, {Leay Kiaw} and {Jia-Yin Hou}, Charles and Lin, {Yen Hung} and Wu, {Vin Cent} and Cheng, {Hao Min} and Kao, {Hsien Li} and Wu, {Kwan Dun} and Lai, {Tai Shuan}",

year = "2024",

month = mar,

doi = "10.1016/j.jfma.2023.04.019",

language = "英语",

volume = "123 Suppl 2",

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journal = "Journal of the Formosan Medical Association",

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T1 - Aldosterone-to-renin ratio (ARR) as a screening tool for primary aldosteronism (PA)

AU - Lin, Chia Hung

AU - Lin, Ching Han

AU - Chung, Mu Chi

AU - Hung, Chi Sheng

AU - Tseng, Fen Yu

AU - Er, Leay Kiaw

AU - Jia-Yin Hou, Charles

AU - Lin, Yen Hung

AU - Wu, Vin Cent

AU - Cheng, Hao Min

AU - Kao, Hsien Li

AU - Wu, Kwan Dun

AU - Lai, Tai Shuan

PY - 2024/3

Y1 - 2024/3

N2 - The aldosterone-to-renin ratio (ARR) is the standard screening test for primary aldosteronism (PA). Because of the poor reproducibility of the ARR, repeat testing is recommended if the result is not compatible with the clinical condition. Various methods to measure renin are used in different hospitals in Taiwan, and the ARR cutoff values also differ among laboratories. The Task Force of Taiwan PA recommend using plasma renin activity (PRA) to calculate ARR instead of direct renin concentration (DRC) unless PRA is unavailable, because PRA is widely used in international guidelines and most studies.

AB - The aldosterone-to-renin ratio (ARR) is the standard screening test for primary aldosteronism (PA). Because of the poor reproducibility of the ARR, repeat testing is recommended if the result is not compatible with the clinical condition. Various methods to measure renin are used in different hospitals in Taiwan, and the ARR cutoff values also differ among laboratories. The Task Force of Taiwan PA recommend using plasma renin activity (PRA) to calculate ARR instead of direct renin concentration (DRC) unless PRA is unavailable, because PRA is widely used in international guidelines and most studies.

KW - Aldosterone

KW - Aldosterone-to-renin ratio

KW - Primary aldosteronism

KW - Renin

KW - Screening

KW - Reproducibility of Results

KW - Hospitals

KW - Humans

KW - Hyperaldosteronism/diagnosis

KW - Hypertension/etiology

UR - http://www.scopus.com/inward/record.url?scp=85158909727&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2023.04.019

DO - 10.1016/j.jfma.2023.04.019

M3 - 文献综述

C2 - 37173226

AN - SCOPUS:85158909727

SN - 0929-6646

VL - 123 Suppl 2

SP - S98-S103

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

ER -

Aldosterone-to-renin ratio (ARR) as a screening tool for primary aldosteronism (PA)

Abstract

Bibliographical note

Keywords

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