Allergic contact dermatitis caused by latanoprost ophthalmic solution

C. H. Lai, I. C. Lai, Ching Chi Chi*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

PURPOSE. Latanoprost is a prostaglandin F2α analog that lowers intraocular pressure by increasing uveoscleral outflow. Herein we describe two cases of allergic contact dermatitis (ACD) to latanoprost. METHODS. A 69-year-old man with open-angle glaucoma developed erythematous erosive swelling of bilateral eyelids after 4 months of latanoprost therapy. An 84-year-old man with open-angle glaucoma had pruritic erythematous plaques on the bilateral lower eyelids after latanoprost therapy for 4 months. RESULTS. In both cases, latanoprost was discontinued and the condition gradually resolved in 1 month. The eyelid lesions recurred in days upon latanoprost rechallenge, but subsided after cessation of rechallenge. CONCLUSIONS. ACD should be suspected if patients on latanoprost therapy have pruritus, erythema, swelling, or erosions on the eyelids even when the symptoms appear after several months of therapy, especially in the elderly.

Original languageEnglish
Pages (from-to)627-629
Number of pages3
JournalEuropean Journal of Ophthalmology
Volume16
Issue number4
DOIs
StatePublished - 2006

Keywords

  • Adverse drug reaction
  • Allergic contact dermatitis
  • Latanoprost

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