Aloe activated P-glycoprotein and CYP 3A: A study on the serum kinetics of aloe and its interaction with cyclosporine in rats

Meng Syuan Yang, Chung Ping Yu, Ching Ya Huang, Pei Dawn Lee Chao, Shiuan Pey Lin*, Yu Chi Hou

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations

Abstract

Aloe, the leaf juice of Aloe vera, is a popular functional food worldwide. The major constituents of aloe are polyphenolic anthranoids such as aloin, aloe-emodin and rhein. Cyclosporine (CSP), an immunosuppressant with a narrow therapeutic window, is a probe substrate of P-glycoprotein (P-gp), an efflux pump, and CYP 3A4. This study first investigated the serum kinetics of aloe, then evaluated the modulation effects of aloe on P-gp and CYP 3A through an aloe-CSP interaction study in rats. The serum kinetic study showed that aloe-emodin glucuronides (G) and rhein sulfates/glucuronides (S/G) were major molecules in the bloodstream. The aloe-CSP interaction study showed that the systemic exposure to CSP was significantly decreased by either a single dose or multiple doses of aloe. The results of in vitro studies indicated that aloe activated P-gp and aloe metabolites activated CYP 3A4. In conclusion, aloe ingestion activated the functions of P-gp and CYP 3A in rats.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalFood and Function
Volume8
Issue number1
DOIs
StatePublished - 01 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

Fingerprint

Dive into the research topics of 'Aloe activated P-glycoprotein and CYP 3A: A study on the serum kinetics of aloe and its interaction with cyclosporine in rats'. Together they form a unique fingerprint.

Cite this