@inproceedings{aeb58c4c01c84f1481f122fede4d4292,
title = "Alpha-fetoprotein detection by using a localized surface plasmon coupled fluorescence fiber-optic biosensor",
abstract = "Alpha-fetoprotein (AFP) detection by using a localized surface plasmon coupled fluorescence (LSPCF) fiber-optic biosensor is setup and experimentally demonstrated. It is based on gold nanoparticle (GNP) and coupled with localized surface plasmon wave on the surface of GNP. In this experiment, the fluorophores are labeled on anti-AFP which are bound to protein A conjugated GNP. Thus, LSPCF is excited with high efficiency in the near field of localized surface plasmon wave. Therefore, not only the sensitivity of LSPCF biosensor is enhanced but also the specific selectivity of AFP is improved. Experimentally, the ability of real time measurement in the range of AFP concentration from 0.1ng/ml to 100ng/ml was detected. To compare with conventional methods such as enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay (RIA), the LSPCF fiber-optic biosensor performs higher or comparable detection sensitivity, respectively.",
keywords = "AFP, Fiber-optic biosensor, Gold nanoparticles, Localized surface plasmon",
author = "Chien Chou and Chang, {Ying Feng} and Chen, {Ran Chou} and Li, {Ying Chang} and Yu, {Chih Jen} and Hsieh, {Bao Yu}",
year = "2008",
doi = "10.1117/12.754617",
language = "英语",
isbn = "9780819470010",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optics in Health Care and Biomedical Optics III",
note = "Optics in Health Care and Biomedical Optics III ; Conference date: 12-11-2007 Through 15-11-2007",
}