Alport syndrome with recurrent herpes simplex virus keratitis

Pei Chen Chung, Ken Kuo Lin, Hu Shien Song, Wan Chen Ku, Samuel C.M. Huang, Chi Chin Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

PURPOSE: To report a case of Alport syndrome with recurrent herpes simplex virus (HSV) keratitis. METHODS: Case report and review of the literature. RESULTS: A 29-year-old man with Alport syndrome suffered from 4 consecutive episodes of HSV keratitis within 2 years. A type IV collagen defect in basement membranes plays an important role in the pathogenesis of Alport syndrome. The relationship between HSV keratitis and Alport syndrome is discussed. After remission from HSV keratitis, the patient underwent bilateral phacoemulsification and posterior-chamber intraocular lens implantation for anterior lenticonus and an anterior polar cataract. After surgery, the uncorrected visual acuity was 20/20 in both eyes. CONCLUSIONS: We assume that the underlying basement membrane defects in Alport syndrome may account for the recurrent episodes of HSV keratitis in this patient. In addition, phacoemulsification and posterior-chamber intraocular lens implantation, rather than correction of refractive errors, provide a safe and efficient therapeutic choice for the management of anterior lenticonus, with or without associated cataract in patients with Alport syndrome.

Original languageEnglish
Pages (from-to)1279-1281
Number of pages3
JournalCornea
Volume26
Issue number10
DOIs
StatePublished - 12 2007
Externally publishedYes

Keywords

  • Alport syndrome
  • Basement membrane
  • Herpes simplex virus keratitis
  • Lenticonus

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