Abstract
Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae. T
Original language | English |
---|---|
Pages (from-to) | 84-88 |
Number of pages | 5 |
Journal | Pathogens and Disease |
Volume | 67 |
Issue number | 1 |
DOIs | |
State | Published - 02 2013 |
Keywords
- Penicillin-binding protein
- Streptococcus pneumoniae
- β-lactam resistance