Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance

Yu Chia Hsieh, Lin Hui Su, Mei Hua Hsu, Cheng Hsun Chiu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae. T

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalPathogens and Disease
Volume67
Issue number1
DOIs
StatePublished - 02 2013

Keywords

  • Penicillin-binding protein
  • Streptococcus pneumoniae
  • β-lactam resistance

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