Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

Rong Fu Chen; Jien Wei Liu; Wen Ting Yeh; Lin Wang; Jen Chieh Chang; Hong Ren Yu; Jiin Tsuey Cheng; Kuender D. Yang

doi:10.1016/j.femsim.2004.11.012

Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

Rong Fu Chen, Jien Wei Liu, Wen Ting Yeh, Lin Wang, Jen Chieh Chang, Hong Ren Yu, Jiin Tsuey Cheng, Kuender D. Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

72 Scopus citations

Abstract

To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	FEMS Immunology and Medical Microbiology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.femsim.2004.11.012
State	Published - 01 04 2005
Externally published	Yes

Keywords

Dengue hemorrhagic fever
GATA-3
Real-time RT-PCR
T-bet
Virus load

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.femsim.2004.11.012

Cite this

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title = "Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever",

abstract = "To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.",

keywords = "Dengue hemorrhagic fever, GATA-3, Real-time RT-PCR, T-bet, Virus load",

author = "Chen, {Rong Fu} and Liu, {Jien Wei} and Yeh, {Wen Ting} and Lin Wang and Chang, {Jen Chieh} and Yu, {Hong Ren} and Cheng, {Jiin Tsuey} and Yang, {Kuender D.}",

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day = "1",

doi = "10.1016/j.femsim.2004.11.012",

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volume = "44",

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journal = "FEMS Immunology and Medical Microbiology",

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AU - Chen, Rong Fu

AU - Liu, Jien Wei

AU - Yeh, Wen Ting

AU - Wang, Lin

AU - Chang, Jen Chieh

AU - Yu, Hong Ren

AU - Cheng, Jiin Tsuey

AU - Yang, Kuender D.

PY - 2005/4/1

Y1 - 2005/4/1

N2 - To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

AB - To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

KW - Dengue hemorrhagic fever

KW - GATA-3

KW - Real-time RT-PCR

KW - T-bet

KW - Virus load

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JO - FEMS Immunology and Medical Microbiology

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IS - 1

ER -

Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

Abstract

Keywords

UN SDGs

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