Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

Rong Fu Chen; Jien Wei Liu; Wen Ting Yeh; Lin Wang; Jen Chieh Chang; Hong Ren Yu; Jiin Tsuey Cheng; Kuender D. Yang

doi:10.1016/j.femsim.2004.11.012

Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

Rong Fu Chen
, Jien Wei Liu
, Wen Ting Yeh
, Lin Wang
, Jen Chieh Chang
, Hong Ren Yu
, Jiin Tsuey Cheng
, Kuender D. Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

74 Scopus citations

Abstract

To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	FEMS Immunology and Medical Microbiology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.femsim.2004.11.012
State	Published - 01 04 2005
Externally published	Yes

Keywords

Dengue hemorrhagic fever
GATA-3
Real-time RT-PCR
T-bet
Virus load

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.femsim.2004.11.012

Cite this

@article{32fffca7636e488183389ce7bac80fac,

title = "Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever",

abstract = "To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.",

keywords = "Dengue hemorrhagic fever, GATA-3, Real-time RT-PCR, T-bet, Virus load",

author = "Chen, \{Rong Fu\} and Liu, \{Jien Wei\} and Yeh, \{Wen Ting\} and Lin Wang and Chang, \{Jen Chieh\} and Yu, \{Hong Ren\} and Cheng, \{Jiin Tsuey\} and Yang, \{Kuender D.\}",

year = "2005",

month = apr,

day = "1",

doi = "10.1016/j.femsim.2004.11.012",

language = "英语",

volume = "44",

pages = "43--50",

journal = "FEMS Immunology and Medical Microbiology",

issn = "0928-8244",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

TY - JOUR

T1 - Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

AU - Chen, Rong Fu

AU - Liu, Jien Wei

AU - Yeh, Wen Ting

AU - Wang, Lin

AU - Chang, Jen Chieh

AU - Yu, Hong Ren

AU - Cheng, Jiin Tsuey

AU - Yang, Kuender D.

PY - 2005/4/1

Y1 - 2005/4/1

N2 - To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

AB - To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

KW - Dengue hemorrhagic fever

KW - GATA-3

KW - Real-time RT-PCR

KW - T-bet

KW - Virus load

UR - https://www.scopus.com/pages/publications/15044363574

U2 - 10.1016/j.femsim.2004.11.012

DO - 10.1016/j.femsim.2004.11.012

M3 - 文章

C2 - 15780577

AN - SCOPUS:15044363574

SN - 0928-8244

VL - 44

SP - 43

EP - 50

JO - FEMS Immunology and Medical Microbiology

JF - FEMS Immunology and Medical Microbiology

IS - 1

ER -

Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this