Alternative activation of macrophages: Concepts and prospects

Siamon Gordon; Laura Helming; Fernando O. Martinez Estrada

doi:10.1007/978-1-4939-1311-4_3

Alternative activation of macrophages: Concepts and prospects

Siamon Gordon^*, Laura Helming, Fernando O. Martinez Estrada

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Macrophages of the body represent a widely dispersed, versatile, and highly responsive homeostatic and defense system. They contribute to innate as well as adaptive immunity to infection, mediating trophic as well as injurious interactions with their local and systemic environment. The concept of macrophage activation has evolved over recent decades, from relatively simple paradigms to bewildering complexity. This chapter will review the background to present understanding of alternative activation of macrophages, consider its relevance to health and disease, and suggest questions for future studies.

Original language	English
Title of host publication	Macrophages
Subtitle of host publication	Biology and Role in the Pathology of Diseases
Publisher	Springer New York
Pages	59-76
Number of pages	18
ISBN (Electronic)	9781493913114
ISBN (Print)	1493913107, 9781493913107
DOIs	https://doi.org/10.1007/978-1-4939-1311-4_3
State	Published - 01 05 2014
Externally published	Yes

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© 2014 Springer Science+Business Media New York. All rights reserved.

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10.1007/978-1-4939-1311-4_3

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Alternative activation of macrophages: Concepts and prospects

Abstract

Bibliographical note

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