TY - JOUR
T1 - Alternative activation of macrophages
T2 - Mechanism and functions
AU - Gordon, Siamon
AU - Martinez, Fernando O.
PY - 2010/5
Y1 - 2010/5
N2 - The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
AB - The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
UR - https://www.scopus.com/pages/publications/77953268611
U2 - 10.1016/j.immuni.2010.05.007
DO - 10.1016/j.immuni.2010.05.007
M3 - 文献综述
C2 - 20510870
AN - SCOPUS:77953268611
SN - 1074-7613
VL - 32
SP - 593
EP - 604
JO - Immunity
JF - Immunity
IS - 5
ER -
