Alternative functions for the multifarious inflammasome

Jan Martel; Hsin Chih Lai; Yun Fei Ko; John D. Young; David M. Ojcius

doi:10.1016/j.bj.2016.06.001

Alternative functions for the multifarious inflammasome

Jan Martel, Hsin Chih Lai, Yun Fei Ko, John D. Young, David M. Ojcius^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.

Original language	English
Pages (from-to)	183-187
Number of pages	5
Journal	Biomedical Journal
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/j.bj.2016.06.001
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Chang Gung University

Keywords

Autophagy
Inflammation
Innate immunity
NLRP3
Non-canonical inflammasome

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10.1016/j.bj.2016.06.001

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title = "Alternative functions for the multifarious inflammasome",

abstract = "The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.",

keywords = "Autophagy, Inflammation, Innate immunity, NLRP3, Non-canonical inflammasome",

author = "Jan Martel and Lai, {Hsin Chih} and Ko, {Yun Fei} and Young, {John D.} and Ojcius, {David M.}",

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AU - Lai, Hsin Chih

AU - Ko, Yun Fei

AU - Young, John D.

AU - Ojcius, David M.

PY - 2016

Y1 - 2016

N2 - The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.

AB - The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.

KW - Autophagy

KW - Inflammation

KW - Innate immunity

KW - NLRP3

KW - Non-canonical inflammasome

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DO - 10.1016/j.bj.2016.06.001

M3 - 短篇评述

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VL - 39

SP - 183

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JO - Biomedical Journal

JF - Biomedical Journal

IS - 3

ER -

Alternative functions for the multifarious inflammasome

Abstract

Bibliographical note

Keywords

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