Amides with anti-platelet aggregation activity from Piper taiwanense

Ih Sheng Chen; Yu Chang Chen; Chang Hui Liao

doi:10.1016/j.fitote.2007.04.009

Amides with anti-platelet aggregation activity from Piper taiwanense

Ih Sheng Chen^*
, Yu Chang Chen
, Chang Hui Liao

^*Corresponding author for this work

School of Traditional Chinese Medicine

Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC₅₀ value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC₅₀ values of 17.3 and 17.4 μM, respectively.

Original language	English
Pages (from-to)	414-419
Number of pages	6
Journal	Fitoterapia
Volume	78
Issue number	6
DOIs	https://doi.org/10.1016/j.fitote.2007.04.009
State	Published - 09 2007

Keywords

Anti-platelet aggregation
Cinnamoylpyrrolidine
N-benzoyltyramine
Piper taiwanense
Taiwanamides

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10.1016/j.fitote.2007.04.009

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title = "Amides with anti-platelet aggregation activity from Piper taiwanense",

abstract = "Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC50 value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC50 values of 17.3 and 17.4 μM, respectively.",

keywords = "Anti-platelet aggregation, Cinnamoylpyrrolidine, N-benzoyltyramine, Piper taiwanense, Taiwanamides",

author = "Chen, \{Ih Sheng\} and Chen, \{Yu Chang\} and Liao, \{Chang Hui\}",

year = "2007",

month = sep,

doi = "10.1016/j.fitote.2007.04.009",

language = "英语",

volume = "78",

pages = "414--419",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Amides with anti-platelet aggregation activity from Piper taiwanense

AU - Chen, Ih Sheng

AU - Chen, Yu Chang

AU - Liao, Chang Hui

PY - 2007/9

Y1 - 2007/9

N2 - Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC50 value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC50 values of 17.3 and 17.4 μM, respectively.

AB - Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC50 value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC50 values of 17.3 and 17.4 μM, respectively.

KW - Anti-platelet aggregation

KW - Cinnamoylpyrrolidine

KW - N-benzoyltyramine

KW - Piper taiwanense

KW - Taiwanamides

UR - https://www.scopus.com/pages/publications/34548027737

U2 - 10.1016/j.fitote.2007.04.009

DO - 10.1016/j.fitote.2007.04.009

M3 - 文章

C2 - 17590283

AN - SCOPUS:34548027737

SN - 0367-326X

VL - 78

SP - 414

EP - 419

JO - Fitoterapia

JF - Fitoterapia

IS - 6

ER -

Amides with anti-platelet aggregation activity from Piper taiwanense

Abstract

Keywords

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