An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?

Claudine Neyen; Subhankar Mukhopadhyay; Siamon Gordon; Thorsten Hagemann

doi:10.4161/onci.24461

An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?

Claudine Neyen, Subhankar Mukhopadhyay, Siamon Gordon, Thorsten Hagemann^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.

Original language	English
Article number	e24461
Journal	OncoImmunology
Volume	2
Issue number	6
DOIs	https://doi.org/10.4161/onci.24461
State	Published - 06 2013
Externally published	Yes

Keywords

Apo A-I mimetic peptide
Co-culture
Ligand
Scavenger receptor
Tumor-associated macrophage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.24461

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title = "An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?",

abstract = "Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.",

keywords = "Apo A-I mimetic peptide, Co-culture, Ligand, Scavenger receptor, Tumor-associated macrophage",

author = "Claudine Neyen and Subhankar Mukhopadhyay and Siamon Gordon and Thorsten Hagemann",

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T2 - A prospective anticancer treatment?

AU - Neyen, Claudine

AU - Mukhopadhyay, Subhankar

AU - Gordon, Siamon

AU - Hagemann, Thorsten

PY - 2013/6

Y1 - 2013/6

N2 - Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.

AB - Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.

KW - Apo A-I mimetic peptide

KW - Co-culture

KW - Ligand

KW - Scavenger receptor

KW - Tumor-associated macrophage

UR - https://www.scopus.com/pages/publications/84886945137

U2 - 10.4161/onci.24461

DO - 10.4161/onci.24461

M3 - 文章

AN - SCOPUS:84886945137

SN - 2162-4011

VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 6

M1 - e24461

ER -

An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?

Abstract

Keywords

UN SDGs

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