An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?

Claudine Neyen; Subhankar Mukhopadhyay; Siamon Gordon; Thorsten Hagemann

doi:10.4161/onci.24461

An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?

Claudine Neyen
, Subhankar Mukhopadhyay
, Siamon Gordon
, Thorsten Hagemann^*

^*Corresponding author for this work

University of Oxford
Queen Mary University of London

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.

Original language	English
Article number	e24461
Journal	OncoImmunology
Volume	2
Issue number	6
DOIs	https://doi.org/10.4161/onci.24461
State	Published - 06 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apo A-I mimetic peptide
Co-culture
Ligand
Scavenger receptor
Tumor-associated macrophage

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10.4161/onci.24461

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title = "An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?",

abstract = "Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.",

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AU - Mukhopadhyay, Subhankar

AU - Gordon, Siamon

AU - Hagemann, Thorsten

PY - 2013/6

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N2 - Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.

AB - Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SR A), hencepromoting tumor progression. We demonstrated that SR A can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.

KW - Apo A-I mimetic peptide

KW - Co-culture

KW - Ligand

KW - Scavenger receptor

KW - Tumor-associated macrophage

UR - https://www.scopus.com/pages/publications/84886945137

U2 - 10.4161/onci.24461

DO - 10.4161/onci.24461

M3 - 文章

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SN - 2162-4011

VL - 2

JO - OncoImmunology

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ER -

An apolipoprotein A-I mimetic targets scavenger receptor a on tumor-associated macrophages: A prospective anticancer treatment?

Abstract

UN SDGs

Keywords

Access to Document

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