Analysis of microelectrographic neuronal background in deep brain nuclei in parkinson disease

  • Hsiao Lung Chan*
  • , Ming An Lin
  • , Tony Wu
  • , Pei Kuang Chao
  • , Shih Tseng Lee
  • , Peng Chuan Chen
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper proposes that spectral characteristics of background neuronal potentials can be effective parameters to classifying and identifying neural activities from subthalamic nucleus (STN) and subtantia nigra (SNr). The spike-free background signals were obtained from inter-spike microelectrode recording signals. The averaged periodogram was then used to compute the power spectral density of the background signals. Three spectral parameters were extracted and used as discriminant features for artificial neural networks. The commonly used neuronal firing patterns were also extracted from the detected neuronal spikes and used as discriminant features. Our results showed that the classification performance based on background parameters was similar or better than using neuronal firing patterns. This implied that neuronal background can be useful as an aid in targeting STN as well as neuronal firing patterns, saving from spike identification as single- or multi-neuron discharges.

Original languageEnglish
Title of host publicationAdvances in Neuro-Information Processing - 15th International Conference, ICONIP 2008, Revised Selected Papers
Pages194-199
Number of pages6
EditionPART 1
DOIs
StatePublished - 2009
Event15th International Conference on Neuro-Information Processing, ICONIP 2008 - Auckland, New Zealand
Duration: 25 11 200828 11 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5506 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference15th International Conference on Neuro-Information Processing, ICONIP 2008
Country/TerritoryNew Zealand
CityAuckland
Period25/11/0828/11/08

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