TY - JOUR
T1 - Analysis of microsatellite instability in cervical cancer
AU - Ou, C. Y.
AU - Chang, J. G.
AU - Tseng, H. H.
AU - Wei, H. J.
AU - Su, T. H.
AU - Hsu, T. Y.
AU - Chang, C. P.
AU - Lee, H. H.
PY - 1999
Y1 - 1999
N2 - Microsatellite instability was first reported in hereditary nonpolyposis colorectal cancer (HNPCC) as well as other cancers, including endometrial and ovarian cancers. Single base repeat markers of human MSH3 and MSH6 genes were found to precipitate the action of human MSH2. The marker BAT-26 was reported to be a simple, low-cost, and rapid marker for detection replication errors (RER) and the status of colorectal cancers. We analyzed di-nucleotide repeats of the microsatellite markers (D2S123, D5S82, D5S299, D10S197, D17S791, D18S34), single base repeat markers (ΔP3, hMSH3, hMSH6, and TGFβ-RII), and BAT-26 to evaluate microsatellite instability in cervical cancer. Altogether 80 paired cervical cancers were studied. Our results showed that microsatellite instability is not common in cervical cancer, and the mutation of the single base repeat of mismatch repair (MMR) genes (hMSH3 and hMSH6) is also uncommon. The BAT-26 is not a good marker to detect the RER status of cervical cancer.
AB - Microsatellite instability was first reported in hereditary nonpolyposis colorectal cancer (HNPCC) as well as other cancers, including endometrial and ovarian cancers. Single base repeat markers of human MSH3 and MSH6 genes were found to precipitate the action of human MSH2. The marker BAT-26 was reported to be a simple, low-cost, and rapid marker for detection replication errors (RER) and the status of colorectal cancers. We analyzed di-nucleotide repeats of the microsatellite markers (D2S123, D5S82, D5S299, D10S197, D17S791, D18S34), single base repeat markers (ΔP3, hMSH3, hMSH6, and TGFβ-RII), and BAT-26 to evaluate microsatellite instability in cervical cancer. Altogether 80 paired cervical cancers were studied. Our results showed that microsatellite instability is not common in cervical cancer, and the mutation of the single base repeat of mismatch repair (MMR) genes (hMSH3 and hMSH6) is also uncommon. The BAT-26 is not a good marker to detect the RER status of cervical cancer.
KW - Cervical cancer
KW - Microsatellite instability
UR - http://www.scopus.com/inward/record.url?scp=0033016853&partnerID=8YFLogxK
U2 - 10.1046/j.1525-1438.1999.09800.x
DO - 10.1046/j.1525-1438.1999.09800.x
M3 - 文章
AN - SCOPUS:0033016853
SN - 1048-891X
VL - 9
SP - 67
EP - 71
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 1
ER -
