Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas

Irina Bonzheim; Eva Geissinger; Wen Yu Chuang; Sabine Roth; Philipp Ströbel; Alexander Marx; Peter Reimer; Martin Wilhelm; Bernhard Puppe; Andreas Rosenwald; Hans Konrad Müller-Hermelink; Thomas Rüdiger

doi:10.1007/s12308-008-0003-y

Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas

Irina Bonzheim^*
, Eva Geissinger
, Wen Yu Chuang
, Sabine Roth
, Philipp Ströbel
, Alexander Marx
, Peter Reimer
, Martin Wilhelm
, Bernhard Puppe
, Andreas Rosenwald
, Hans Konrad Müller-Hermelink
, Thomas Rüdiger

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT.

Original language	English
Pages (from-to)	11-21
Number of pages	11
Journal	Journal of Hematopathology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1007/s12308-008-0003-y
State	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angioimmunoblastic T-cell lymphoma
Apoptosis
Autoimmune diseases
CTLA-4
FAS
Single nucleotide polymorphism

Access to Document

10.1007/s12308-008-0003-y

Cite this

@article{7e9cf6cbcdea43c4ac4d277d70335bb2,

title = "Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas",

abstract = "Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT.",

keywords = "Angioimmunoblastic T-cell lymphoma, Apoptosis, Autoimmune diseases, CTLA-4, FAS, Single nucleotide polymorphism",

author = "Irina Bonzheim and Eva Geissinger and Chuang, \{Wen Yu\} and Sabine Roth and Philipp Str{\"o}bel and Alexander Marx and Peter Reimer and Martin Wilhelm and Bernhard Puppe and Andreas Rosenwald and M{\"u}ller-Hermelink, \{Hans Konrad\} and Thomas R{\"u}diger",

year = "2008",

doi = "10.1007/s12308-008-0003-y",

language = "英语",

volume = "1",

pages = "11--21",

journal = "Journal of Hematopathology",

issn = "1865-5785",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas

AU - Bonzheim, Irina

AU - Geissinger, Eva

AU - Chuang, Wen Yu

AU - Roth, Sabine

AU - Ströbel, Philipp

AU - Marx, Alexander

AU - Reimer, Peter

AU - Wilhelm, Martin

AU - Puppe, Bernhard

AU - Rosenwald, Andreas

AU - Müller-Hermelink, Hans Konrad

AU - Rüdiger, Thomas

PY - 2008

Y1 - 2008

N2 - Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT.

AB - Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occurred at a different frequency compared to healthy individuals. Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT.

KW - Angioimmunoblastic T-cell lymphoma

KW - Apoptosis

KW - Autoimmune diseases

KW - CTLA-4

KW - FAS

KW - Single nucleotide polymorphism

UR - https://www.scopus.com/pages/publications/84874666752

U2 - 10.1007/s12308-008-0003-y

DO - 10.1007/s12308-008-0003-y

M3 - 文章

AN - SCOPUS:84874666752

SN - 1865-5785

VL - 1

SP - 11

EP - 21

JO - Journal of Hematopathology

JF - Journal of Hematopathology

IS - 1

ER -

Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this