Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan; C. S. Lu; R. Peng; Y. Y. Teo; Y. H. Wu-Chou; R. S. Chen; Y. H. Weng; C. M. Chen; H. C. Fung; L. C. Tan; Z. J. Zhang; X. K. An; G. J. Lee-Chen; M. C. Lee; S. Fook-Chong; J. M. Burgunder; R. M. Wu; Y. R. Wu

doi:10.1016/j.neurobiolaging.2008.11.008

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan
, C. S. Lu
, R. Peng
, Y. Y. Teo
, Y. H. Wu-Chou
, R. S. Chen
, Y. H. Weng
, C. M. Chen
, H. C. Fung
, L. C. Tan
, Z. J. Zhang
, X. K. An
, G. J. Lee-Chen
, M. C. Lee
, S. Fook-Chong
, J. M. Burgunder
, R. M. Wu
, Y. R. Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

Original language	English
Pages (from-to)	2194-2196
Number of pages	3
Journal	Neurobiology of Aging
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.11.008
State	Published - 12 2010
Externally published	Yes

Keywords

Parkinson's disease
Polymorphism
UCHL1

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10.1016/j.neurobiolaging.2008.11.008

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Tan, E. K., Lu, C. S., Peng, R., Teo, Y. Y., Wu-Chou, Y. H., Chen, R. S., Weng, Y. H., Chen, C. M., Fung, H. C., Tan, L. C., Zhang, Z. J., An, X. K., Lee-Chen, G. J., Lee, M. C., Fook-Chong, S., Burgunder, J. M., Wu, R. M., & Wu, Y. R. (2010). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging, 31(12), 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

@article{53b4c00c71354931a23b3f1e4e02448d,

title = "Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese",

abstract = "The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95\% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95\% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.",

keywords = "Parkinson's disease, Polymorphism, UCHL1",

author = "Tan, \{E. K.\} and Lu, \{C. S.\} and R. Peng and Teo, \{Y. Y.\} and Wu-Chou, \{Y. H.\} and Chen, \{R. S.\} and Weng, \{Y. H.\} and Chen, \{C. M.\} and Fung, \{H. C.\} and Tan, \{L. C.\} and Zhang, \{Z. J.\} and An, \{X. K.\} and Lee-Chen, \{G. J.\} and Lee, \{M. C.\} and S. Fook-Chong and Burgunder, \{J. M.\} and Wu, \{R. M.\} and Wu, \{Y. R.\}",

year = "2010",

month = dec,

doi = "10.1016/j.neurobiolaging.2008.11.008",

language = "英语",

volume = "31",

pages = "2194--2196",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "12",

}

Tan, EK, Lu, CS, Peng, R, Teo, YY, Wu-Chou, YH, Chen, RS, Weng, YH, Chen, CM, Fung, HC, Tan, LC, Zhang, ZJ, An, XK, Lee-Chen, GJ, Lee, MC, Fook-Chong, S, Burgunder, JM, Wu, RM & Wu, YR 2010, 'Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese', Neurobiology of Aging, vol. 31, no. 12, pp. 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

TY - JOUR

T1 - Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

AU - Tan, E. K.

AU - Lu, C. S.

AU - Peng, R.

AU - Teo, Y. Y.

AU - Wu-Chou, Y. H.

AU - Chen, R. S.

AU - Weng, Y. H.

AU - Chen, C. M.

AU - Fung, H. C.

AU - Tan, L. C.

AU - Zhang, Z. J.

AU - An, X. K.

AU - Lee-Chen, G. J.

AU - Lee, M. C.

AU - Fook-Chong, S.

AU - Burgunder, J. M.

AU - Wu, R. M.

AU - Wu, Y. R.

PY - 2010/12

Y1 - 2010/12

N2 - The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

AB - The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

KW - Parkinson's disease

KW - Polymorphism

KW - UCHL1

UR - https://www.scopus.com/pages/publications/78650174666

U2 - 10.1016/j.neurobiolaging.2008.11.008

DO - 10.1016/j.neurobiolaging.2008.11.008

M3 - 文章

C2 - 19329225

AN - SCOPUS:78650174666

SN - 0197-4580

VL - 31

SP - 2194

EP - 2196

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 12

ER -

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

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Keywords

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