Anatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus-endemic area in Taiwan

Chien Hung Chen; Mei Hui Wang; Jing Houng Wang; Chao Hung Hung; Tsung Hui Hu; Shui Cheng Lee; Hung Da Tung; Chuan Mo Lee; Chi Sin Changchien; Pao Fei Chen; Mei Chin Hsu; Sheng Nan Lu

doi:10.4269/ajtmh.2007.77.747

Anatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus-endemic area in Taiwan

Chien Hung Chen
, Mei Hui Wang
, Jing Houng Wang
, Chao Hung Hung
, Tsung Hui Hu
, Shui Cheng Lee
, Hung Da Tung
, Chuan Mo Lee
, Chi Sin Changchien
, Pao Fei Chen
, Mei Chin Hsu
, Sheng Nan Lu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

32 Scopus citations

Abstract

This community-based study evaluated the role of aflatoxin exposure in advanced liver disease in hepatitis C virus (HCV)-endemic townships. Preventive health examination was performed on 314 adults ≥ 40 years of age recruited from HCV-endemic townships in Tainan, Taiwan. Aflatoxin-albumin in serum was quantified by a new enzyme-linked immunosorbent assay method. After adjusting serum albumin levels and platelet counts, aflatoxin-Bi albumin adducts was still an independent risk factor for advanced liver disease among all 314 residents (> 8 versus ≤ 8 (AFBi)-albumin/albumin; OR = 2.29, 95% CI =1.23-4.27, P = 0.009) and particularly in anti-HCV-positive subjects (OR = 2.09, 95% CI = 1.09-4.0, P = 0.026). Levels of AFB1-albumin/albumin were significantly related to ultrasonographic parenchyma scores (P < 0.001, one-way ANOVA) in all and anti-HCV-positive subjects. The findings indicated aflatoxin exposure may be associated with advanced liver disease in chronic hepatitis C patients in HCV-endemic regions in Taiwan.

Original language	English
Pages (from-to)	747-752
Number of pages	6
Journal	American Journal of Tropical Medicine and Hygiene
Volume	77
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.2007.77.747
State	Published - 10 2007
Externally published	Yes

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Chen, C. H., Wang, M. H., Wang, J. H., Hung, C. H., Hu, T. H., Lee, S. C., Tung, H. D., Lee, C. M., Changchien, C. S., Chen, P. F., Hsu, M. C., & Lu, S. N. (2007). Anatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus-endemic area in Taiwan. American Journal of Tropical Medicine and Hygiene, 77(4), 747-752. https://doi.org/10.4269/ajtmh.2007.77.747

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title = "Anatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus-endemic area in Taiwan",

abstract = "This community-based study evaluated the role of aflatoxin exposure in advanced liver disease in hepatitis C virus (HCV)-endemic townships. Preventive health examination was performed on 314 adults ≥ 40 years of age recruited from HCV-endemic townships in Tainan, Taiwan. Aflatoxin-albumin in serum was quantified by a new enzyme-linked immunosorbent assay method. After adjusting serum albumin levels and platelet counts, aflatoxin-Bi albumin adducts was still an independent risk factor for advanced liver disease among all 314 residents (> 8 versus ≤ 8 (AFBi)-albumin/albumin; OR = 2.29, 95\% CI =1.23-4.27, P = 0.009) and particularly in anti-HCV-positive subjects (OR = 2.09, 95\% CI = 1.09-4.0, P = 0.026). Levels of AFB1-albumin/albumin were significantly related to ultrasonographic parenchyma scores (P < 0.001, one-way ANOVA) in all and anti-HCV-positive subjects. The findings indicated aflatoxin exposure may be associated with advanced liver disease in chronic hepatitis C patients in HCV-endemic regions in Taiwan.",

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AU - Hu, Tsung Hui

AU - Lee, Shui Cheng

AU - Tung, Hung Da

AU - Lee, Chuan Mo

AU - Changchien, Chi Sin

AU - Chen, Pao Fei

AU - Hsu, Mei Chin

AU - Lu, Sheng Nan

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N2 - This community-based study evaluated the role of aflatoxin exposure in advanced liver disease in hepatitis C virus (HCV)-endemic townships. Preventive health examination was performed on 314 adults ≥ 40 years of age recruited from HCV-endemic townships in Tainan, Taiwan. Aflatoxin-albumin in serum was quantified by a new enzyme-linked immunosorbent assay method. After adjusting serum albumin levels and platelet counts, aflatoxin-Bi albumin adducts was still an independent risk factor for advanced liver disease among all 314 residents (> 8 versus ≤ 8 (AFBi)-albumin/albumin; OR = 2.29, 95% CI =1.23-4.27, P = 0.009) and particularly in anti-HCV-positive subjects (OR = 2.09, 95% CI = 1.09-4.0, P = 0.026). Levels of AFB1-albumin/albumin were significantly related to ultrasonographic parenchyma scores (P < 0.001, one-way ANOVA) in all and anti-HCV-positive subjects. The findings indicated aflatoxin exposure may be associated with advanced liver disease in chronic hepatitis C patients in HCV-endemic regions in Taiwan.

AB - This community-based study evaluated the role of aflatoxin exposure in advanced liver disease in hepatitis C virus (HCV)-endemic townships. Preventive health examination was performed on 314 adults ≥ 40 years of age recruited from HCV-endemic townships in Tainan, Taiwan. Aflatoxin-albumin in serum was quantified by a new enzyme-linked immunosorbent assay method. After adjusting serum albumin levels and platelet counts, aflatoxin-Bi albumin adducts was still an independent risk factor for advanced liver disease among all 314 residents (> 8 versus ≤ 8 (AFBi)-albumin/albumin; OR = 2.29, 95% CI =1.23-4.27, P = 0.009) and particularly in anti-HCV-positive subjects (OR = 2.09, 95% CI = 1.09-4.0, P = 0.026). Levels of AFB1-albumin/albumin were significantly related to ultrasonographic parenchyma scores (P < 0.001, one-way ANOVA) in all and anti-HCV-positive subjects. The findings indicated aflatoxin exposure may be associated with advanced liver disease in chronic hepatitis C patients in HCV-endemic regions in Taiwan.

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DO - 10.4269/ajtmh.2007.77.747

M3 - 文章

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AN - SCOPUS:38449092178

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JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

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ER -

Anatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus-endemic area in Taiwan

Abstract

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