Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway

Shyng Shiou F. Yuan, Hsueh Ling Chang, Hsiao Wen Chen, Yao Tsung Yeh, Ying Hsien Kao, Kuei Hsiang Lin, Yang Chang Wu*, Jinu Huang Su

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

106 Scopus citations

Abstract

Annonaceous acetogenins are a group of potential anti-neoplastic agents isolated from Annonaceae plants. In this study, we purified annonacin, a cytotoxic mono-tetrahydrofuran acetogenin, from the seeds of Annona reticulata and analyzed its biological effects. Herein, we have shown that annonacin caused significant cell death in various cancer cell lines. T24 bladder cancer cells at the S phase were more vulnerable to the cytotoxicity of annonacin. Furthermore, annonacin activated p21 in a p53-independent manner and arrested T24 cells at the G1 phase. It also induced Bax expression, enhanced caspase-3 activity, and caused apoptotic cell death in T24 cells. In summary, these results suggest that annonacin is potentially a promising anti-cancer compound.

Original languageEnglish
Pages (from-to)2853-2861
Number of pages9
JournalLife Sciences
Volume72
Issue number25
DOIs
StatePublished - 09 05 2003

Keywords

  • Acetogenins
  • Annona reticulata
  • Annonaceae
  • Annonacin
  • Apoptosis
  • Cell cycle checkpoints
  • Cytotoxicity

Fingerprint

Dive into the research topics of 'Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway'. Together they form a unique fingerprint.

Cite this