Anti-cancer and anti-inflammatory activities of three new chromone derivatives from the marine-derived penicillium citrinum

Yi Cheng Chu; Chun Hao Chang; Hsiang Ruei Liao; Shu Ling Fu; Jih Jung Chen

doi:10.3390/md19080408

Anti-cancer and anti-inflammatory activities of three new chromone derivatives from the marine-derived penicillium citrinum

Yi Cheng Chu, Chun Hao Chang, Hsiang Ruei Liao, Shu Ling Fu, Jih Jung Chen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

15 Scopus citations

Abstract

Three new and uncommon chromone analogs, epiremisporine F (1), epiremisporine G (2), and epiremisporine H (3), were isolated from marine-origin Penicillium citrinum. Among the isolated compounds, compounds 2–3 remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC₅₀ values of 31.68 ± 2.53, and 33.52 ± 0.42 µM, respectively. Compound 3 exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC₅₀ values of 21.17 ± 4.89 and 31.43 ± 3.01 µM, respectively, and Western blot assay confirmed that compound 3 obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.

Original language	English
Article number	408
Journal	Marine Drugs
Volume	19
Issue number	8
DOIs	https://doi.org/10.3390/md19080408
State	Published - 08 2021

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Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Anti-cancer activity
Anti-inflammatory activity
Chromone derivatives
Penicillium citrinum

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10.3390/md19080408

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title = "Anti-cancer and anti-inflammatory activities of three new chromone derivatives from the marine-derived penicillium citrinum",

abstract = "Three new and uncommon chromone analogs, epiremisporine F (1), epiremisporine G (2), and epiremisporine H (3), were isolated from marine-origin Penicillium citrinum. Among the isolated compounds, compounds 2–3 remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 31.68 ± 2.53, and 33.52 ± 0.42 µM, respectively. Compound 3 exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC50 values of 21.17 ± 4.89 and 31.43 ± 3.01 µM, respectively, and Western blot assay confirmed that compound 3 obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.",

keywords = "Anti-cancer activity, Anti-inflammatory activity, Chromone derivatives, Penicillium citrinum",

author = "Chu, {Yi Cheng} and Chang, {Chun Hao} and Liao, {Hsiang Ruei} and Fu, {Shu Ling} and Chen, {Jih Jung}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = aug,

doi = "10.3390/md19080408",

language = "英语",

volume = "19",

journal = "Marine Drugs",

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T1 - Anti-cancer and anti-inflammatory activities of three new chromone derivatives from the marine-derived penicillium citrinum

AU - Chu, Yi Cheng

AU - Chang, Chun Hao

AU - Liao, Hsiang Ruei

AU - Fu, Shu Ling

AU - Chen, Jih Jung

PY - 2021/8

Y1 - 2021/8

N2 - Three new and uncommon chromone analogs, epiremisporine F (1), epiremisporine G (2), and epiremisporine H (3), were isolated from marine-origin Penicillium citrinum. Among the isolated compounds, compounds 2–3 remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 31.68 ± 2.53, and 33.52 ± 0.42 µM, respectively. Compound 3 exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC50 values of 21.17 ± 4.89 and 31.43 ± 3.01 µM, respectively, and Western blot assay confirmed that compound 3 obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.

AB - Three new and uncommon chromone analogs, epiremisporine F (1), epiremisporine G (2), and epiremisporine H (3), were isolated from marine-origin Penicillium citrinum. Among the isolated compounds, compounds 2–3 remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 31.68 ± 2.53, and 33.52 ± 0.42 µM, respectively. Compound 3 exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC50 values of 21.17 ± 4.89 and 31.43 ± 3.01 µM, respectively, and Western blot assay confirmed that compound 3 obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.

KW - Anti-cancer activity

KW - Anti-inflammatory activity

KW - Chromone derivatives

KW - Penicillium citrinum

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U2 - 10.3390/md19080408

DO - 10.3390/md19080408

M3 - 文章

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AN - SCOPUS:85111555797

SN - 1660-3397

VL - 19

JO - Marine Drugs

JF - Marine Drugs

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ER -

Anti-cancer and anti-inflammatory activities of three new chromone derivatives from the marine-derived penicillium citrinum

Abstract

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Keywords

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