Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid: Comanthus bennetti

Li Chai Chen; Yen You Lin; Yen Hsuan Jean; Yi Lu; Wu Fu Chen; San Nan Yang; Hui Min David Wang; Ing Yang Jang; I. Ming Chen; Jui Hsin Su; Ping Jyun Sung; Jyh Horng Sheu; Zhi Hong Wen

doi:10.3390/molecules190914667

Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid: Comanthus bennetti

Li Chai Chen
, Yen You Lin
, Yen Hsuan Jean
, Yi Lu
, Wu Fu Chen
, San Nan Yang
, Hui Min David Wang
, Ing Yang Jang
, I. Ming Chen
, Jui Hsin Su
, Ping Jyun Sung
, Jyh Horng Sheu
, Zhi Hong Wen^*

^*Corresponding author for this work

National Sun Yat-sen University
Kaohsiung Armed Forces General Hospital
Ping Tung Christian Hospital, Taiwan
Chang Gung University
I-Shou University
Kaohsiung Medical University
Wenzao Ursuline University of Languages
National Dong Hwa University
National Museum of Marine Biology and Aquarium, Taiwan

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain.

Original language	English
Pages (from-to)	14667-14686
Number of pages	20
Journal	Molecules
Volume	19
Issue number	9
DOIs	https://doi.org/10.3390/molecules190914667
State	Published - 16 09 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

Carrageenan
Comanthus bennetti
Comaparvin
Crinoids
Inducible nitric oxide synthase
Lipopolysaccharide

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10.3390/molecules190914667

Cite this

Chen, L. C., Lin, Y. Y., Jean, Y. H., Lu, Y., Chen, W. F., Yang, S. N., David Wang, H. M., Jang, I. Y., Chen, I. M., Su, J. H., Sung, P. J., Sheu, J. H., & Wen, Z. H. (2014). Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid: Comanthus bennetti. Molecules, 19(9), 14667-14686. https://doi.org/10.3390/molecules190914667

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title = "Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid: Comanthus bennetti",

abstract = "To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain.",

keywords = "Carrageenan, Comanthus bennetti, Comaparvin, Crinoids, Inducible nitric oxide synthase, Lipopolysaccharide",

author = "Chen, \{Li Chai\} and Lin, \{Yen You\} and Jean, \{Yen Hsuan\} and Yi Lu and Chen, \{Wu Fu\} and Yang, \{San Nan\} and \{David Wang\}, \{Hui Min\} and Jang, \{Ing Yang\} and Chen, \{I. Ming\} and Su, \{Jui Hsin\} and Sung, \{Ping Jyun\} and Sheu, \{Jyh Horng\} and Wen, \{Zhi Hong\}",

note = "Publisher Copyright: {\textcopyright} 2014 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2014",

month = sep,

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doi = "10.3390/molecules190914667",

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T2 - Comanthus bennetti

AU - Chen, Li Chai

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AU - Jean, Yen Hsuan

AU - Lu, Yi

AU - Chen, Wu Fu

AU - Yang, San Nan

AU - David Wang, Hui Min

AU - Jang, Ing Yang

AU - Chen, I. Ming

AU - Su, Jui Hsin

AU - Sung, Ping Jyun

AU - Sheu, Jyh Horng

AU - Wen, Zhi Hong

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AB - To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain.

KW - Carrageenan

KW - Comanthus bennetti

KW - Comaparvin

KW - Crinoids

KW - Inducible nitric oxide synthase

KW - Lipopolysaccharide

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ER -

Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid: Comanthus bennetti

Abstract

Bibliographical note

Keywords

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