Anti-inflammatory and antioxidant components from hygroryza aristata

Yu Ming Chung; Yu Hsuan Lan; Tsong Long Hwang; Yann Lii Leu

doi:10.3390/molecules16031917

Anti-inflammatory and antioxidant components from hygroryza aristata

Yu Ming Chung, Yu Hsuan Lan, Tsong Long Hwang, Yann Lii Leu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7'R*,8'S*)-icariol A₂-9-O-ß- xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC₅₀ values of 19.33 ± 0.86 and 24.14 ± 1.59 μM, respectively.

Original language	English
Pages (from-to)	1917-1927
Number of pages	11
Journal	Molecules
Volume	16
Issue number	3
DOIs	https://doi.org/10.3390/molecules16031917
State	Published - 03 2011

Keywords

Anti-inflammatory
Antioxidant
Gramineae
Hygarine
Hygroryza aristata

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title = "Anti-inflammatory and antioxidant components from hygroryza aristata",

abstract = "Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7'R*,8'S*)-icariol A2-9-O-{\ss}- xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 ± 0.86 and 24.14 ± 1.59 μM, respectively.",

keywords = "Anti-inflammatory, Antioxidant, Gramineae, Hygarine, Hygroryza aristata",

author = "Chung, {Yu Ming} and Lan, {Yu Hsuan} and Hwang, {Tsong Long} and Leu, {Yann Lii}",

year = "2011",

month = mar,

doi = "10.3390/molecules16031917",

language = "英语",

volume = "16",

pages = "1917--1927",

journal = "Molecules",

issn = "1420-3049",

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number = "3",

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TY - JOUR

T1 - Anti-inflammatory and antioxidant components from hygroryza aristata

AU - Chung, Yu Ming

AU - Lan, Yu Hsuan

AU - Hwang, Tsong Long

AU - Leu, Yann Lii

PY - 2011/3

Y1 - 2011/3

N2 - Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7'R*,8'S*)-icariol A2-9-O-ß- xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 ± 0.86 and 24.14 ± 1.59 μM, respectively.

AB - Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7'R*,8'S*)-icariol A2-9-O-ß- xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 ± 0.86 and 24.14 ± 1.59 μM, respectively.

KW - Anti-inflammatory

KW - Antioxidant

KW - Gramineae

KW - Hygarine

KW - Hygroryza aristata

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U2 - 10.3390/molecules16031917

DO - 10.3390/molecules16031917

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SN - 1420-3049

VL - 16

SP - 1917

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JO - Molecules

JF - Molecules

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Anti-inflammatory and antioxidant components from hygroryza aristata

Abstract

Keywords

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