Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia

Chia Lin Lee; Ming Hon Yen; Tsong Long Hwang; Juan Cheng Yang; Chieh Yu Peng; Chao Jung Chen; Wen Yi Chang; Yang Chang Wu

doi:10.1016/j.phytol.2015.04.012

Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia

Chia Lin Lee^*, Ming Hon Yen, Tsong Long Hwang, Juan Cheng Yang, Chieh Yu Peng, Chao Jung Chen, Wen Yi Chang, Yang Chang Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

8 Scopus citations

Abstract

Abstract Portulide glucoside A (1), 14-acetoxy-9-epi-britanlin A (2), and dichroditerpene A (3) along with eight known compounds were isolated from Dichrocephala integrifolia. Diterpenoids 3 and 5 showed antineutrophilic inflammatory activities against not only superoxide anion generation with IC₅₀ values of 1.74 and 4.40 μM, but also elastase release with IC₅₀ values of 1.32 and 3.67 μM, respectively. Additionally, sinapyl alcohols 8 and 9 showed moderate cytotoxicity toward DU145 human prostate cancer cell line with IC₅₀ values of 24.1 and 19.0 μM, respectively. Isolates 1-10 were found for the first time in this plant.

Original language	English
Article number	931
Pages (from-to)	237-242
Number of pages	6
Journal	Phytochemistry Letters
Volume	12
DOIs	https://doi.org/10.1016/j.phytol.2015.04.012
State	Published - 16 06 2015

Bibliographical note

Publisher Copyright:
© 2015 Phytochemical Society of Europe.

Keywords

Anti-inflammatory effect
Asteraceae
Cytotoxicity
Dichrocephala integrifolia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2015.04.012

Cite this

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title = "Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia",

abstract = "Abstract Portulide glucoside A (1), 14-acetoxy-9-epi-britanlin A (2), and dichroditerpene A (3) along with eight known compounds were isolated from Dichrocephala integrifolia. Diterpenoids 3 and 5 showed antineutrophilic inflammatory activities against not only superoxide anion generation with IC50 values of 1.74 and 4.40 μM, but also elastase release with IC50 values of 1.32 and 3.67 μM, respectively. Additionally, sinapyl alcohols 8 and 9 showed moderate cytotoxicity toward DU145 human prostate cancer cell line with IC50 values of 24.1 and 19.0 μM, respectively. Isolates 1-10 were found for the first time in this plant.",

keywords = "Anti-inflammatory effect, Asteraceae, Cytotoxicity, Dichrocephala integrifolia",

author = "Lee, {Chia Lin} and Yen, {Ming Hon} and Hwang, {Tsong Long} and Yang, {Juan Cheng} and Peng, {Chieh Yu} and Chen, {Chao Jung} and Chang, {Wen Yi} and Wu, {Yang Chang}",

note = "Publisher Copyright: {\textcopyright} 2015 Phytochemical Society of Europe.",

year = "2015",

month = jun,

day = "16",

doi = "10.1016/j.phytol.2015.04.012",

language = "英语",

volume = "12",

pages = "237--242",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia

AU - Lee, Chia Lin

AU - Yen, Ming Hon

AU - Hwang, Tsong Long

AU - Yang, Juan Cheng

AU - Peng, Chieh Yu

AU - Chen, Chao Jung

AU - Chang, Wen Yi

AU - Wu, Yang Chang

PY - 2015/6/16

Y1 - 2015/6/16

N2 - Abstract Portulide glucoside A (1), 14-acetoxy-9-epi-britanlin A (2), and dichroditerpene A (3) along with eight known compounds were isolated from Dichrocephala integrifolia. Diterpenoids 3 and 5 showed antineutrophilic inflammatory activities against not only superoxide anion generation with IC50 values of 1.74 and 4.40 μM, but also elastase release with IC50 values of 1.32 and 3.67 μM, respectively. Additionally, sinapyl alcohols 8 and 9 showed moderate cytotoxicity toward DU145 human prostate cancer cell line with IC50 values of 24.1 and 19.0 μM, respectively. Isolates 1-10 were found for the first time in this plant.

AB - Abstract Portulide glucoside A (1), 14-acetoxy-9-epi-britanlin A (2), and dichroditerpene A (3) along with eight known compounds were isolated from Dichrocephala integrifolia. Diterpenoids 3 and 5 showed antineutrophilic inflammatory activities against not only superoxide anion generation with IC50 values of 1.74 and 4.40 μM, but also elastase release with IC50 values of 1.32 and 3.67 μM, respectively. Additionally, sinapyl alcohols 8 and 9 showed moderate cytotoxicity toward DU145 human prostate cancer cell line with IC50 values of 24.1 and 19.0 μM, respectively. Isolates 1-10 were found for the first time in this plant.

KW - Anti-inflammatory effect

KW - Asteraceae

KW - Cytotoxicity

KW - Dichrocephala integrifolia

UR - http://www.scopus.com/inward/record.url?scp=84931269304&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2015.04.012

DO - 10.1016/j.phytol.2015.04.012

M3 - 文章

AN - SCOPUS:84931269304

SN - 1874-3900

VL - 12

SP - 237

EP - 242

JO - Phytochemistry Letters

JF - Phytochemistry Letters

M1 - 931

ER -

Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia

Abstract

Bibliographical note

Keywords

UN SDGs

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