Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

Chia Lin Lee; Tsong Long Hwang; Chieh Yu Peng; Chao Jung Chen; Chao Lin Kuo; Wen Yi Chang; Yang Chang Wu

doi:10.1177/1934578x1501000235

Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

Chia Lin Lee, Tsong Long Hwang, Chieh Yu Peng, Chao Jung Chen, Chao Lin Kuo, Wen Yi Chang, Yang Chang Wu

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 ìM; especially, 3 inhibited elastase release with an IC50 value of 4.0 ìM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 ìM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 ìM, respectively.

Original language	English
Pages (from-to)	345-348
Number of pages	4
Journal	Natural Product Communications
Volume	10
Issue number	2
DOIs	https://doi.org/10.1177/1934578x1501000235
State	Published - 02 2015

Keywords

Anti-inflammation
Cytotoxicity
Solanaceae
Solanum macaonense

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x1501000235

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@article{25e64d4c7e684b4ba04cec6d1fb2c661,

title = "Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense",

abstract = "One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 {\`i}M; especially, 3 inhibited elastase release with an IC50 value of 4.0 {\`i}M. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 {\`i}M. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 {\`i}M, respectively.",

keywords = "Anti-inflammation, Cytotoxicity, Solanaceae, Solanum macaonense",

author = "Lee, {Chia Lin} and Hwang, {Tsong Long} and Peng, {Chieh Yu} and Chen, {Chao Jung} and Kuo, {Chao Lin} and Chang, {Wen Yi} and Wu, {Yang Chang}",

year = "2015",

month = feb,

doi = "10.1177/1934578x1501000235",

language = "英语",

volume = "10",

pages = "345--348",

journal = "Natural Product Communications",

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TY - JOUR

T1 - Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

AU - Lee, Chia Lin

AU - Hwang, Tsong Long

AU - Peng, Chieh Yu

AU - Chen, Chao Jung

AU - Kuo, Chao Lin

AU - Chang, Wen Yi

AU - Wu, Yang Chang

PY - 2015/2

Y1 - 2015/2

N2 - One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 ìM; especially, 3 inhibited elastase release with an IC50 value of 4.0 ìM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 ìM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 ìM, respectively.

AB - One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 ìM; especially, 3 inhibited elastase release with an IC50 value of 4.0 ìM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 ìM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 ìM, respectively.

KW - Anti-inflammation

KW - Cytotoxicity

KW - Solanaceae

KW - Solanum macaonense

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U2 - 10.1177/1934578x1501000235

DO - 10.1177/1934578x1501000235

M3 - 文章

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AN - SCOPUS:84930977799

SN - 1934-578X

VL - 10

SP - 345

EP - 348

JO - Natural Product Communications

JF - Natural Product Communications

IS - 2

ER -

Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

Abstract

Keywords

UN SDGs

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