Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula

Fang Rong Chang; Tsong Long Hwang; Yu Liang Yang; Chia En Li; Chin Chung Wu; Hamad H. Issa; Wen Bin Hsieh; Yang Chang Wu

doi:10.1055/s-2006-951691

Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula

Fang Rong Chang
, Tsong Long Hwang
, Yu Liang Yang
, Chia En Li
, Chin Chung Wu
, Hamad H. Issa
, Wen Bin Hsieh
, Yang Chang Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Kaohsiung Medical University
Ten-Chen General Hospital

Research output: Contribution to journal › Journal Article › peer-review

84 Scopus citations

Abstract

A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5-7, 10, and 24 were obtained for the first time from the family Annonaceae. The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2-4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC₅₀ = 0.60 ± 0.09 μg/mL.

Original language	English
Pages (from-to)	1344-1347
Number of pages	4
Journal	Planta Medica
Volume	72
Issue number	14
DOIs	https://doi.org/10.1055/s-2006-951691
State	Published - 11 2006

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@article{35584a37b1ce480c8397d83d51e949c6,

title = "Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula",

abstract = "A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5-7, 10, and 24 were obtained for the first time from the family Annonaceae. The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2-4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC50 = 0.60 ± 0.09 μg/mL.",

author = "Chang, \{Fang Rong\} and Hwang, \{Tsong Long\} and Yang, \{Yu Liang\} and Li, \{Chia En\} and Wu, \{Chin Chung\} and Issa, \{Hamad H.\} and Hsieh, \{Wen Bin\} and Wu, \{Yang Chang\}",

year = "2006",

month = nov,

doi = "10.1055/s-2006-951691",

language = "英语",

volume = "72",

pages = "1344--1347",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "14",

}

TY - JOUR

T1 - Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula

AU - Chang, Fang Rong

AU - Hwang, Tsong Long

AU - Yang, Yu Liang

AU - Li, Chia En

AU - Wu, Chin Chung

AU - Issa, Hamad H.

AU - Hsieh, Wen Bin

AU - Wu, Yang Chang

PY - 2006/11

Y1 - 2006/11

N2 - A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5-7, 10, and 24 were obtained for the first time from the family Annonaceae. The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2-4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC50 = 0.60 ± 0.09 μg/mL.

AB - A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5-7, 10, and 24 were obtained for the first time from the family Annonaceae. The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2-4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC50 = 0.60 ± 0.09 μg/mL.

UR - https://www.scopus.com/pages/publications/33845243613

U2 - 10.1055/s-2006-951691

DO - 10.1055/s-2006-951691

M3 - 文章

C2 - 17022008

AN - SCOPUS:33845243613

SN - 0032-0943

VL - 72

SP - 1344

EP - 1347

JO - Planta Medica

JF - Planta Medica

IS - 14

ER -

Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula

Abstract

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