TY - JOUR
T1 - Anti-inflammatory biphenyls and dibenzofurans from Rhaphiolepis indica
AU - Lin, Chu Hung
AU - Chang, Hsun Shuo
AU - Liao, Chang Hui
AU - Ou, Tai Hsin
AU - Chen, Ih Sheng
AU - Tsai, Ian Lih
PY - 2010/10/22
Y1 - 2010/10/22
N2 - Bioassay-guided fractionation of the methanolic extract of the roots of Rhaphiolepis indica var. tashiroi afforded four new dibenzofurans, 2-hydroxy-3,4,6-trimethoxydibenzofuran (1), 2-hydroxy-3,4,9- trimethoxydibenzofuran (2), 2-hydroxy-3,4,6,9-tetramethoxydibenzofuran (3), and 1,2-methylenedioxy-3,4,6-trimethoxydibenzofuran (4), two new biphenyls, 3-hydroxy-2′,5-dimethoxybiphenyl (5) and 2′,3-dihydroxy-5- methoxybiphenyl (6), and 3-hydroxy-5-methoxybiphenyl (7). Among the isolates, 3, 5, and 6 exhibited inhibitory effects on N-formyl-methionyl-leucyl- phenylalanine (fMLP)-induced superoxide production, with in vitro IC 50 values < 8.36 μM.
AB - Bioassay-guided fractionation of the methanolic extract of the roots of Rhaphiolepis indica var. tashiroi afforded four new dibenzofurans, 2-hydroxy-3,4,6-trimethoxydibenzofuran (1), 2-hydroxy-3,4,9- trimethoxydibenzofuran (2), 2-hydroxy-3,4,6,9-tetramethoxydibenzofuran (3), and 1,2-methylenedioxy-3,4,6-trimethoxydibenzofuran (4), two new biphenyls, 3-hydroxy-2′,5-dimethoxybiphenyl (5) and 2′,3-dihydroxy-5- methoxybiphenyl (6), and 3-hydroxy-5-methoxybiphenyl (7). Among the isolates, 3, 5, and 6 exhibited inhibitory effects on N-formyl-methionyl-leucyl- phenylalanine (fMLP)-induced superoxide production, with in vitro IC 50 values < 8.36 μM.
UR - http://www.scopus.com/inward/record.url?scp=77958546009&partnerID=8YFLogxK
U2 - 10.1021/np100200s
DO - 10.1021/np100200s
M3 - 文章
C2 - 20839880
AN - SCOPUS:77958546009
SN - 0163-3864
VL - 73
SP - 1628
EP - 1631
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 10
ER -