Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

Te An Kung; Lo Yun Chen; Chia Ying Li; Bo Rong Peng; Tsong Long Hwang; Ping Jyun Sung; Kuei Hung Lai; Hsu Ming Chung

doi:10.1016/j.phytol.2023.03.004

Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

Te An Kung, Lo Yun Chen, Chia Ying Li, Bo Rong Peng, Tsong Long Hwang, Ping Jyun Sung, Kuei Hung Lai^*, Hsu Ming Chung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydroxycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1–5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.

Original language	English
Pages (from-to)	12-16
Number of pages	5
Journal	Phytochemistry Letters
Volume	55
DOIs	https://doi.org/10.1016/j.phytol.2023.03.004
State	Published - 06 2023

Bibliographical note

Publisher Copyright:
© 2023 Phytochemical Society of Europe

Keywords

Anti-inflammation
Cembranoid
Elastase release
Sinularia querciformis

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10.1016/j.phytol.2023.03.004

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@article{3d4e31d2744b4ae7a5ff558221900095,

title = "Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis",

abstract = "The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydroxycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1–5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.",

keywords = "Anti-inflammation, Cembranoid, Elastase release, Sinularia querciformis",

author = "Kung, {Te An} and Chen, {Lo Yun} and Li, {Chia Ying} and Peng, {Bo Rong} and Hwang, {Tsong Long} and Sung, {Ping Jyun} and Lai, {Kuei Hung} and Chung, {Hsu Ming}",

note = "Publisher Copyright: {\textcopyright} 2023 Phytochemical Society of Europe",

year = "2023",

month = jun,

doi = "10.1016/j.phytol.2023.03.004",

language = "英语",

volume = "55",

pages = "12--16",

journal = "Phytochemistry Letters",

issn = "1874-3900",

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T1 - Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

AU - Kung, Te An

AU - Chen, Lo Yun

AU - Li, Chia Ying

AU - Peng, Bo Rong

AU - Hwang, Tsong Long

AU - Sung, Ping Jyun

AU - Lai, Kuei Hung

AU - Chung, Hsu Ming

PY - 2023/6

Y1 - 2023/6

N2 - The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydroxycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1–5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.

AB - The exploration of Sinularia querciformis cembranoids afforded two new compounds, querciformolide G (1) and H (2), along with three known ones, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydroxycembra-15(17)-en-1,12-olide (5). The structural elucidation of these compounds was achieved by extensive spectroscopic (IR, ESIMS, 1D and 2D NMR data) analysis and by comparison with those previously reported in the literature. Compounds 1–5 were evaluated for their anti-inflammatory activity. Among all, compound 1 displayed significant inhibitory effects on the elastase release in activated human neutrophils.

KW - Anti-inflammation

KW - Cembranoid

KW - Elastase release

KW - Sinularia querciformis

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U2 - 10.1016/j.phytol.2023.03.004

DO - 10.1016/j.phytol.2023.03.004

M3 - 文章

AN - SCOPUS:85149853559

SN - 1874-3900

VL - 55

SP - 12

EP - 16

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

Abstract

Bibliographical note

Keywords

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