Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo; Hsin Yi Hung; Tsong Long Hwang; Wen Ke Du; Hsiang Chih Ku; E. Jian Lee; Shih Huang Tai; Fu An Chen; Tian Shung Wu

doi:10.1021/acs.jnatprod.7b00039

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo, Hsin Yi Hung, Tsong Long Hwang, Wen Ke Du, Hsiang Chih Ku, E. Jian Lee, Shih Huang Tai, Fu An Chen, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

Original language	English
Pages (from-to)	783-789
Number of pages	7
Journal	Journal of Natural Products
Volume	80
Issue number	4
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00039
State	Published - 28 04 2017

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Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.

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title = "Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco",

abstract = "Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.",

author = "Kuo, \{Ping Chung\} and Hung, \{Hsin Yi\} and Hwang, \{Tsong Long\} and Du, \{Wen Ke\} and Ku, \{Hsiang Chih\} and Lee, \{E. Jian\} and Tai, \{Shih Huang\} and Chen, \{Fu An\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2017 The American Chemical Society and American Society of Pharmacognosy.",

year = "2017",

month = apr,

day = "28",

doi = "10.1021/acs.jnatprod.7b00039",

language = "英语",

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T1 - Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Hwang, Tsong Long

AU - Du, Wen Ke

AU - Ku, Hsiang Chih

AU - Lee, E. Jian

AU - Tai, Shih Huang

AU - Chen, Fu An

AU - Wu, Tian Shung

PY - 2017/4/28

Y1 - 2017/4/28

N2 - Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

AB - Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

UR - https://www.scopus.com/pages/publications/85018440849

U2 - 10.1021/acs.jnatprod.7b00039

DO - 10.1021/acs.jnatprod.7b00039

M3 - 文章

C2 - 28398735

AN - SCOPUS:85018440849

SN - 0163-3864

VL - 80

SP - 783

EP - 789

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Abstract

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