Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica

Yaun Chao Huang; Tsong Long Hwang; Chih Shiang Chang; Yu Liang Yang; Chia Ning Shen; Wen Ying Liao; Sheng Chih Chen; Chih Chuang Liaw

doi:10.1021/np900148a

Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica

Yaun Chao Huang, Tsong Long Hwang, Chih Shiang Chang, Yu Liang Yang, Chia Ning Shen, Wen Ying Liao, Sheng Chih Chen, Chih Chuang Liaw^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

57 Scopus citations

Abstract

Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4′-dihydroxy-4″,4″- dimethyl-5″-methyl-5″ H-dihydrofurano[2″,3″:6,7] flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (FMLP/CB).

Original language	English
Pages (from-to)	1273-1278
Number of pages	6
Journal	Journal of Natural Products
Volume	72
Issue number	7
DOIs	https://doi.org/10.1021/np900148a
State	Published - 24 07 2009

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10.1021/np900148a

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title = "Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica",

abstract = "Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4′-dihydroxy-4″,4″- dimethyl-5″-methyl-5″ H-dihydrofurano[2″,3″:6,7] flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (FMLP/CB).",

author = "Huang, {Yaun Chao} and Hwang, {Tsong Long} and Chang, {Chih Shiang} and Yang, {Yu Liang} and Shen, {Chia Ning} and Liao, {Wen Ying} and Chen, {Sheng Chih} and Liaw, {Chih Chuang}",

year = "2009",

month = jul,

day = "24",

doi = "10.1021/np900148a",

language = "英语",

volume = "72",

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journal = "Journal of Natural Products",

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publisher = "American Chemical Society",

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}

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T1 - Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica

AU - Huang, Yaun Chao

AU - Hwang, Tsong Long

AU - Chang, Chih Shiang

AU - Yang, Yu Liang

AU - Shen, Chia Ning

AU - Liao, Wen Ying

AU - Chen, Sheng Chih

AU - Liaw, Chih Chuang

PY - 2009/7/24

Y1 - 2009/7/24

N2 - Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4′-dihydroxy-4″,4″- dimethyl-5″-methyl-5″ H-dihydrofurano[2″,3″:6,7] flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (FMLP/CB).

AB - Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4′-dihydroxy-4″,4″- dimethyl-5″-methyl-5″ H-dihydrofurano[2″,3″:6,7] flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (FMLP/CB).

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U2 - 10.1021/np900148a

DO - 10.1021/np900148a

M3 - 文章

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SN - 0163-3864

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SP - 1273

EP - 1278

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 7

ER -

Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica

Abstract

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