Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma

Keh Shaw Chen; Pei Wen Hsieh; Tsong Long Hwang; Fang Rong Chang; Yang Chang Wu

doi:10.1080/14786410410001714669

Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma

Keh Shaw Chen, Pei Wen Hsieh, Tsong Long Hwang, Fang Rong Chang, Yang Chang Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC₅₀ of 1 and 2 were found to be 3.21 and 8.48 μg/mL, respectively.

Original language	English
Pages (from-to)	283-286
Number of pages	4
Journal	Natural Product Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1080/14786410410001714669
State	Published - 04 2005

Keywords

Anti-inflammatory
Linderalactone
Neolitsea parvigemma
Neutrophil
Pseudoneolinderane

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title = "Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma",

abstract = "Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 μg/mL, respectively.",

keywords = "Anti-inflammatory, Linderalactone, Neolitsea parvigemma, Neutrophil, Pseudoneolinderane",

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AU - Chen, Keh Shaw

AU - Hsieh, Pei Wen

AU - Hwang, Tsong Long

AU - Chang, Fang Rong

AU - Wu, Yang Chang

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AB - Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 μg/mL, respectively.

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KW - Linderalactone

KW - Neolitsea parvigemma

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ER -

Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma

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Keywords

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