Anti-inflammatory neolignans from the roots of Magnolia officinalis

Hung Cheng Shih, Ping Chung Kuo, Shwu Jen Wu, Tsong Long Hwang, Hsin Yi Hung, De Yang Shen, Po Chuen Shieh, Yu Ren Liao, E. Jian Lee, Qiong Gu, Kuo Hsiung Lee*, Tian Shung Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations

Abstract

Nine neolignan derivatives (1-9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10-24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,2'-dihydroxy-3-methoxy-5,5'-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 μM and 2.16 to 3.39 μM, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents.

Original languageEnglish
Pages (from-to)1439-1445
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume24
Issue number7
DOIs
StatePublished - 01 04 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.

Keywords

  • Anti-inflammatory activity
  • Houpulins E-M
  • Magnolia officinalis
  • Neolignans

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