Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo; Yi Hung Wu; Hsin Yi Hung; Sio Hong Lam; Guo Hao Ma; Liang Mou Kuo; Tsong Long Hwang; Daih Huang Kuo; Tian Shung Wu

doi:10.1016/j.bmcl.2020.127224

Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo
, Yi Hung Wu
, Hsin Yi Hung
, Sio Hong Lam
, Guo Hao Ma
, Liang Mou Kuo
, Tsong Long Hwang
, Daih Huang Kuo
, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Cheng Kung University
National Chung Hsing University
Chang Gung Memorial Hospital
Chang Gung University
Tajen University

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC₅₀ values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Original language	English
Article number	127224
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	30
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2020.127224
State	Published - 01 07 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

Alkaloid
Anti-inflammatory
Benzenoid glycoside
Elastase release
Sesquiterpene
Superoxide anion generation

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10.1016/j.bmcl.2020.127224

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title = "Anti-inflammatory principles from Lindera aggregata",

abstract = "Four new sesquiterpenes (1{\textendash}4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.",

keywords = "Alkaloid, Anti-inflammatory, Benzenoid glycoside, Elastase release, Sesquiterpene, Superoxide anion generation",

author = "Kuo, \{Ping Chung\} and Wu, \{Yi Hung\} and Hung, \{Hsin Yi\} and Lam, \{Sio Hong\} and Ma, \{Guo Hao\} and Kuo, \{Liang Mou\} and Hwang, \{Tsong Long\} and Kuo, \{Daih Huang\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jul,

day = "1",

doi = "10.1016/j.bmcl.2020.127224",

language = "英语",

volume = "30",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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TY - JOUR

T1 - Anti-inflammatory principles from Lindera aggregata

AU - Kuo, Ping Chung

AU - Wu, Yi Hung

AU - Hung, Hsin Yi

AU - Lam, Sio Hong

AU - Ma, Guo Hao

AU - Kuo, Liang Mou

AU - Hwang, Tsong Long

AU - Kuo, Daih Huang

AU - Wu, Tian Shung

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

AB - Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

KW - Alkaloid

KW - Anti-inflammatory

KW - Benzenoid glycoside

KW - Elastase release

KW - Sesquiterpene

KW - Superoxide anion generation

UR - https://www.scopus.com/pages/publications/85083885393

U2 - 10.1016/j.bmcl.2020.127224

DO - 10.1016/j.bmcl.2020.127224

M3 - 文章

C2 - 32359855

AN - SCOPUS:85083885393

SN - 0960-894X

VL - 30

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

M1 - 127224

ER -

Anti-inflammatory principles from Lindera aggregata

Abstract

Bibliographical note

Keywords

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