Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: Influence of L-NAME and aspirin

Shen Kou Tsai*, Cheng Hsiung Huang, Shiang Suo Huang, Li Man Hung, Chuang Ye Hong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

75 Scopus citations

Abstract

This study was designed to evaluate the in vivo effect of magnolol and honokiol on the acute phase of coronary ligation in the presence of nitric oxide inhibitor (L-NAME) or cyclooxygenase inhibitor (aspirin). After Sprague-Dawley rats were anesthetized with urethane, the changes of ventricular arrhythmia induced by coronary ligation for 30 min were determined with or without pretreatment with study medications. The incidence and duration of ventricular arrhythmia were significantly reduced after intravenous pretreatment (15 min before coronary ligation)with 10-7 g/kg magnolol or 10-7 g/kg honokiol. However, the antiarrhythmic effect of magnolol or honokiol could be abolished with the pretreatment of 1 mg/kg L-NAME, but not with pretreatment of 100 mg/kg aspirin. The abolishment of the myocardial beneficial effect of magnolol and honokiol by L-NAME, instead of aspirin, suggests an involvement of an increased nitric oxide synthesis in the protection offered by magnolol and honokiol against arrhythmia during myocardial ischemia.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalPharmacology
Volume59
Issue number5
DOIs
StatePublished - 11 1999
Externally publishedYes

Keywords

  • Aspirin
  • Coronary occlusion
  • Honokiol
  • L-NAME
  • Magnolol

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