TY - JOUR
T1 - Antiepileptic effects of low frequency repetitive transcranial magnetic stimulation
T2 - A meta-analysis
AU - Hsu, Wan Yu
AU - Cheng, Chia Hsiung
AU - Lin, Ming Wei
AU - Shih, Yang Hsin
AU - Liao, Kwong Kum
AU - Lin, Yung Yang
PY - 2011/10
Y1 - 2011/10
N2 - Purpose: To evaluate the antiepileptic efficacy of low frequency repetitive transcranial magnetic stimulation (rTMS) in medically intractable epilepsy. Methods: A comprehensive literature search was performed on articles published from 1990 to 2010 in Medline, Pubmed, CINAHL, and Cochrane using the following keywords: epilepsy, seizure, transcranial magnetic stimulation, repetitive transcranial magnetic stimulation. Two reviewers assessed article eligibility and extracted the data independently. For outcome measures, effect size and 95% confidence interval (CI) were calculated for seizure frequency, spike number, duration of epileptiform abnormalities (EAs), and resting motor threshold (RMT) by using fixed and random effect models. Results: Eleven articles were identified, with a total of 164 participants. Based on seizure frequency, a significant effect size was found (effect size: 0.34, with a 95% CI at 0.10-0.57). Considering between-study heterogeneity, we conducted a second meta-analysis, and the underlying etiology was considered important for the treatment effect. Cortical dysplasia or neocortical epilepsy showed an effect size of 0.71, with a 95% CI at 0.30-1.12. In contrast, other epileptic disorders showed an effect size of 0.22. Conclusion: Low frequency rTMS has a favorable effect on seizure reduction, particularly evident in patients with neocortical epilepsy or cortical dysplasia.
AB - Purpose: To evaluate the antiepileptic efficacy of low frequency repetitive transcranial magnetic stimulation (rTMS) in medically intractable epilepsy. Methods: A comprehensive literature search was performed on articles published from 1990 to 2010 in Medline, Pubmed, CINAHL, and Cochrane using the following keywords: epilepsy, seizure, transcranial magnetic stimulation, repetitive transcranial magnetic stimulation. Two reviewers assessed article eligibility and extracted the data independently. For outcome measures, effect size and 95% confidence interval (CI) were calculated for seizure frequency, spike number, duration of epileptiform abnormalities (EAs), and resting motor threshold (RMT) by using fixed and random effect models. Results: Eleven articles were identified, with a total of 164 participants. Based on seizure frequency, a significant effect size was found (effect size: 0.34, with a 95% CI at 0.10-0.57). Considering between-study heterogeneity, we conducted a second meta-analysis, and the underlying etiology was considered important for the treatment effect. Cortical dysplasia or neocortical epilepsy showed an effect size of 0.71, with a 95% CI at 0.30-1.12. In contrast, other epileptic disorders showed an effect size of 0.22. Conclusion: Low frequency rTMS has a favorable effect on seizure reduction, particularly evident in patients with neocortical epilepsy or cortical dysplasia.
KW - Antiepileptic effect
KW - Epilepsy
KW - Low frequency
KW - Meta-analysis
KW - Repetitive transcranial magnetic stimulation (rTMS)
UR - http://www.scopus.com/inward/record.url?scp=80053916937&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2011.06.002
DO - 10.1016/j.eplepsyres.2011.06.002
M3 - 文章
C2 - 21715144
AN - SCOPUS:80053916937
SN - 0920-1211
VL - 96
SP - 231
EP - 240
JO - Epilepsy Research
JF - Epilepsy Research
IS - 3
ER -