Abstract
Aim: Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Methodology: The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison. Results: The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71-3.42 and 1.71-6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress. Conclusion: SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.
| Original language | English |
|---|---|
| Pages (from-to) | 657-671 |
| Number of pages | 15 |
| Journal | Nanomedicine |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| State | Published - 03 2016 |
Bibliographical note
Publisher Copyright:© 2016 Future Medicine Ltd.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- antimicrobial
- methicillin-resistant S. aureus
- micelle
- skin
- soyaethyl morpholinium ethosulfate
Fingerprint
Dive into the research topics of 'Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver