Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species

Shih Chun Yang; Ibrahim A. Aljuffali; Calvin T. Sung; Chwan Fwu Lin; Jia You Fang

doi:10.2217/nnm.15.217

Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species

Shih Chun Yang, Ibrahim A. Aljuffali, Calvin T. Sung, Chwan Fwu Lin, Jia You Fang^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Aim: Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Methodology: The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison. Results: The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71-3.42 and 1.71-6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress. Conclusion: SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.

Original language	English
Pages (from-to)	657-671
Number of pages	15
Journal	Nanomedicine
Volume	11
Issue number	6
DOIs	https://doi.org/10.2217/nnm.15.217
State	Published - 03 2016

Bibliographical note

Publisher Copyright:
© 2016 Future Medicine Ltd.

Keywords

antimicrobial
methicillin-resistant S. aureus
micelle
skin
soyaethyl morpholinium ethosulfate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm.15.217

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title = "Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species",

abstract = "Aim: Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Methodology: The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison. Results: The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71-3.42 and 1.71-6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress. Conclusion: SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.",

keywords = "antimicrobial, methicillin-resistant S. aureus, micelle, skin, soyaethyl morpholinium ethosulfate",

author = "Yang, \{Shih Chun\} and Aljuffali, \{Ibrahim A.\} and Sung, \{Calvin T.\} and Lin, \{Chwan Fwu\} and Fang, \{Jia You\}",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = mar,

doi = "10.2217/nnm.15.217",

language = "英语",

volume = "11",

pages = "657--671",

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T1 - Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species

AU - Yang, Shih Chun

AU - Aljuffali, Ibrahim A.

AU - Sung, Calvin T.

AU - Lin, Chwan Fwu

AU - Fang, Jia You

PY - 2016/3

Y1 - 2016/3

N2 - Aim: Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Methodology: The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison. Results: The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71-3.42 and 1.71-6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress. Conclusion: SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.

AB - Aim: Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Methodology: The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison. Results: The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71-3.42 and 1.71-6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress. Conclusion: SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.

KW - antimicrobial

KW - methicillin-resistant S. aureus

KW - micelle

KW - skin

KW - soyaethyl morpholinium ethosulfate

UR - https://www.scopus.com/pages/publications/84962124731

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DO - 10.2217/nnm.15.217

M3 - 文章

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SN - 1743-5889

VL - 11

SP - 657

EP - 671

JO - Nanomedicine

JF - Nanomedicine

IS - 6

ER -

Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species

Abstract

Bibliographical note

Keywords

UN SDGs

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