Antiplatelet, antioxidative, and anti-inflammatory effects of hydroquinone

Mei Chi Chang, Bei En Chang, Yu Hwa Pan, Bor Ru Lin, Yun Chia Lian, Ming Shu Lee, Sin Yuet Yeung, Li Deh Lin*, Jiiang Huei Jeng

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

Platelets play crucial roles in thrombosis and hemostasis through platelet activation and aggregation that are crucial in cardiovascular diseases. Hydroquinone (HQ) and its derivatives are present in many dermatological creams, paints, motor fuels, air, microorganisms, and plant products like wheat bread, fruit, coffee, and red wine. The effect of HQ on humans is not clear. In this study, we found that HQ (>25 μM) inhibited arachidonic acid (AA)-induced platelet aggregation. HQ suppressed AA-induced thromboxane B2 production of platelets. HQ (>10 μM) also attenuated ex vivo platelet-rich plasma aggregation. HQ prevented the interleukin (IL)-1β-induced 8-isoprostane, and PGE2 production, but not IL-8 production of pulp cells. These results indicate that HQ may have an antiplatelet effect via inhibition of thromboxane production. HQ has antioxidative and anti-inflammatory effects, and possible inhibition of COX. Exposure and consumption of HQ-containing products, food or drugs may have antiplatelet, antioxidative, and anti-inflammatory effects.

Original languageEnglish
Pages (from-to)18123-18130
Number of pages8
JournalJournal of Cellular Physiology
Volume234
Issue number10
DOIs
StatePublished - 10 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Keywords

  • anti-inflammatory
  • antioxidant
  • cardiovascular diseases
  • hydroquinone (HQ)
  • platelet aggregation
  • reactive oxygen species (ROS)
  • thromboxane

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