TY - JOUR
T1 - Antiretroviral therapy adherence and viral suppression in HIV-infected drug users
T2 - Comparison of self-report and electronic monitoring
AU - Arnsten, J. H.
AU - Demas, P. A.
AU - Farzadegan, H.
AU - Grant, R. W.
AU - Gourevitch, M. N.
AU - Chang, C. J.
AU - Buono, D.
AU - Eckholdt, H.
AU - Howard, A. A.
AU - Schoenbaum, E. E.
PY - 2001/10/15
Y1 - 2001/10/15
N2 - To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. Adherence (percentage of doses taken as prescribed) was calculated for both the day and the week preceding each of 6 research visits. Mean self-reported 1-day adherence was 79% (median, 86%), and mean self-reported 1-week adherence was 78% (median, 85%). Mean MEMS 1-day adherence was 57% (median, 52%), and mean MEMS 1-week adherence was 53% (median, 49%). One-day and 1-week estimates were highly correlated (r>.8 for both measures). Both self-reported and MEMS adherence were correlated with concurrent HIV load (r=.43-.60), but the likelihood of achieving virologic suppression was greater if MEMS adherence was high than if self-reported adherence was high. We conclude that self-reported adherence is higher than MEMS adherence, but a strong relationship exists between both measures and virus load. However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies.
AB - To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. Adherence (percentage of doses taken as prescribed) was calculated for both the day and the week preceding each of 6 research visits. Mean self-reported 1-day adherence was 79% (median, 86%), and mean self-reported 1-week adherence was 78% (median, 85%). Mean MEMS 1-day adherence was 57% (median, 52%), and mean MEMS 1-week adherence was 53% (median, 49%). One-day and 1-week estimates were highly correlated (r>.8 for both measures). Both self-reported and MEMS adherence were correlated with concurrent HIV load (r=.43-.60), but the likelihood of achieving virologic suppression was greater if MEMS adherence was high than if self-reported adherence was high. We conclude that self-reported adherence is higher than MEMS adherence, but a strong relationship exists between both measures and virus load. However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies.
UR - https://www.scopus.com/pages/publications/0035887958
U2 - 10.1086/323201
DO - 10.1086/323201
M3 - 文章
C2 - 11550118
AN - SCOPUS:0035887958
SN - 1058-4838
VL - 33
SP - 1417
EP - 1423
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 8
ER -
