Antisense oligodeoxynucleotides to c-jun inhibits proliferation of transformed NIH 3T3 cells induced by E5a of HPV-11

Show Li Chen; Lo Ti Tsao; Yeou Ping Tsao

doi:10.1016/0304-3835(94)90247-X

Antisense oligodeoxynucleotides to c-jun inhibits proliferation of transformed NIH 3T3 cells induced by E5a of HPV-11

Show Li Chen, Lo Ti Tsao, Yeou Ping Tsao^*

^*Corresponding author for this work

National Defense Medical Center Taiwan

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

E5a of HPV-11 is a transforming oncogene. Previously, we had shown that the E5a gene is required only for the initiation of transformation; c-jun might be involved in the maintenance of transformation. In this study, we exposed E5a transformed NIH 3T3 cells to antisense oligodeoxynucleotides complementary to the 24 nucleotides corresponding to the translation initiation site of the c-jun gene, and examined the effects of this treatment on cell proliferation. Results show that antisense c-jun oligodeoxynucleotides could repress c-jun production and inhibit cell proliferation in E5a transformed cells.

Original language	English
Pages (from-to)	119-123
Number of pages	5
Journal	Cancer Letters
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)90247-X
State	Published - 30 09 1994
Externally published	Yes

Keywords

Antisense oligonucleotides
E5a oncoprotein
HPV-11
c-jun

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(94)90247-X

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title = "Antisense oligodeoxynucleotides to c-jun inhibits proliferation of transformed NIH 3T3 cells induced by E5a of HPV-11",

abstract = "E5a of HPV-11 is a transforming oncogene. Previously, we had shown that the E5a gene is required only for the initiation of transformation; c-jun might be involved in the maintenance of transformation. In this study, we exposed E5a transformed NIH 3T3 cells to antisense oligodeoxynucleotides complementary to the 24 nucleotides corresponding to the translation initiation site of the c-jun gene, and examined the effects of this treatment on cell proliferation. Results show that antisense c-jun oligodeoxynucleotides could repress c-jun production and inhibit cell proliferation in E5a transformed cells.",

keywords = "Antisense oligonucleotides, E5a oncoprotein, HPV-11, c-jun",

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year = "1994",

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doi = "10.1016/0304-3835(94)90247-X",

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T1 - Antisense oligodeoxynucleotides to c-jun inhibits proliferation of transformed NIH 3T3 cells induced by E5a of HPV-11

AU - Chen, Show Li

AU - Tsao, Lo Ti

AU - Tsao, Yeou Ping

PY - 1994/9/30

Y1 - 1994/9/30

N2 - E5a of HPV-11 is a transforming oncogene. Previously, we had shown that the E5a gene is required only for the initiation of transformation; c-jun might be involved in the maintenance of transformation. In this study, we exposed E5a transformed NIH 3T3 cells to antisense oligodeoxynucleotides complementary to the 24 nucleotides corresponding to the translation initiation site of the c-jun gene, and examined the effects of this treatment on cell proliferation. Results show that antisense c-jun oligodeoxynucleotides could repress c-jun production and inhibit cell proliferation in E5a transformed cells.

AB - E5a of HPV-11 is a transforming oncogene. Previously, we had shown that the E5a gene is required only for the initiation of transformation; c-jun might be involved in the maintenance of transformation. In this study, we exposed E5a transformed NIH 3T3 cells to antisense oligodeoxynucleotides complementary to the 24 nucleotides corresponding to the translation initiation site of the c-jun gene, and examined the effects of this treatment on cell proliferation. Results show that antisense c-jun oligodeoxynucleotides could repress c-jun production and inhibit cell proliferation in E5a transformed cells.

KW - Antisense oligonucleotides

KW - E5a oncoprotein

KW - HPV-11

KW - c-jun

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DO - 10.1016/0304-3835(94)90247-X

M3 - 文章

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AN - SCOPUS:0028147157

SN - 0304-3835

VL - 85

SP - 119

EP - 123

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Antisense oligodeoxynucleotides to c-jun inhibits proliferation of transformed NIH 3T3 cells induced by E5a of HPV-11

Abstract

Keywords

UN SDGs

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