TY - JOUR
T1 - APC/CTNNB1 (β-catenin) pathway alterations in human prostate cancers
AU - Gerstein, Amy V.
AU - Almeida, Teresa Acosta
AU - Zhao, Guojing
AU - Chess, Eric
AU - Shih, Ie Ming
AU - Buhler, Kent
AU - Pienta, Kenneth
AU - Rubin, Mark A.
AU - Vessella, Robert
AU - Papadopoulos, Nickolas
PY - 2002
Y1 - 2002
N2 - Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. It was previously shown that 5% of prostate tumors harbor CTNNB1 mutations, suggesting that this tumor type may involve a deregulated APC/CTNNB1 pathway. To explore this possibility further, we searched for mutations in genes implicated in this pathway in 22 samples that included cell lines, xenografts, and primary tumors. We identified seven alterations: two in CTNNB1, three in APC, and two in hTRCP1 (also known as BTRC) which controls the degradation of CTNNB1. Alterations in the CTNNB1 regulatory domain, APC, and hTRCP1 were mutually exclusive, consistent with their equivalent effects on CTNNB1 stability. These results suggest that CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers. Moreover, they provide the first evidence that hTRCP1 plays a role in human neoplasia.
AB - Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. It was previously shown that 5% of prostate tumors harbor CTNNB1 mutations, suggesting that this tumor type may involve a deregulated APC/CTNNB1 pathway. To explore this possibility further, we searched for mutations in genes implicated in this pathway in 22 samples that included cell lines, xenografts, and primary tumors. We identified seven alterations: two in CTNNB1, three in APC, and two in hTRCP1 (also known as BTRC) which controls the degradation of CTNNB1. Alterations in the CTNNB1 regulatory domain, APC, and hTRCP1 were mutually exclusive, consistent with their equivalent effects on CTNNB1 stability. These results suggest that CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers. Moreover, they provide the first evidence that hTRCP1 plays a role in human neoplasia.
UR - http://www.scopus.com/inward/record.url?scp=18344363708&partnerID=8YFLogxK
U2 - 10.1002/gcc.10037
DO - 10.1002/gcc.10037
M3 - 文章
C2 - 11921277
AN - SCOPUS:18344363708
SN - 1045-2257
VL - 34
SP - 9
EP - 16
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
IS - 1
ER -
