Apolipoprotein E Polymorphism and Behavioral and Psychological Symptoms of Dementia in Patients With Alzheimer Disease

Cheng-Sheng Chen; Pei Ouyang; Yi-Chun Yeh; Chiou-Lian Lai; Ching-Kuan Liu; Cheng-Fang Yen; Chih-Hung Ko; Ju-Yu Yen; Gin-Chun Liu; Suh-Hang Hank Juo

doi:10.1097/WAD.0b013e31821f5787

Apolipoprotein E Polymorphism and Behavioral and Psychological Symptoms of Dementia in Patients With Alzheimer Disease

Cheng-Sheng Chen, Pei Ouyang, Yi-Chun Yeh, Chiou-Lian Lai, Ching-Kuan Liu, Cheng-Fang Yen, Chih-Hung Ko, Ju-Yu Yen, Gin-Chun Liu, Suh-Hang Hank Juo

Department of Physiology

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

The aims of this study were to identify subsyndromes of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer disease (AD), and to investigate whether the apolipoprotein E (ApoE) gene confers a risk of distinct BPSD subsyndromes. BPSD of 96 patients with AD were assessed using the Neuropsychiatric Inventory. Factor analysis with principal component analysis and varimax rotation was used to construct the BPSD subsyndromes. ApoE genotypes were determined using the TaqMan technology. The results showed that the 5 subsyndromes can be determined, including: agitation/aggression-delusion, euphoria-disinhibition, depression-apathy, hallucination-nighttime behavior, and appetite. ApoE epsilon 4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome. We demonstrated that ApoE epsilon 4 confers a higher risk for the subsyndrome of agitation/aggression delusion in AD.

Original language	American English
Pages (from-to)	135-139
Journal	ALZHEIMER DISEASE & ASSOCIATED DISORDERS
Volume	26
Issue number	2
DOIs	https://doi.org/10.1097/WAD.0b013e31821f5787
State	Published - 2012

Keywords

AGGRESSIVE-BEHAVIOR
Alzheimer disease
ApoE gene
BIOLOGICAL ASPECTS
CORTEX
E GENOTYPE
EPSILON-4 ALLELE
LATE-ONSET
LEWY BODIES
NEUROPSYCHIATRIC INVENTORY
NONCOGNITIVE SYMPTOMS
PSYCHOTIC SYMPTOMS
agitation
delusion

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title = "Apolipoprotein E Polymorphism and Behavioral and Psychological Symptoms of Dementia in Patients With Alzheimer Disease",

abstract = "The aims of this study were to identify subsyndromes of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer disease (AD), and to investigate whether the apolipoprotein E (ApoE) gene confers a risk of distinct BPSD subsyndromes. BPSD of 96 patients with AD were assessed using the Neuropsychiatric Inventory. Factor analysis with principal component analysis and varimax rotation was used to construct the BPSD subsyndromes. ApoE genotypes were determined using the TaqMan technology. The results showed that the 5 subsyndromes can be determined, including: agitation/aggression-delusion, euphoria-disinhibition, depression-apathy, hallucination-nighttime behavior, and appetite. ApoE epsilon 4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome. We demonstrated that ApoE epsilon 4 confers a higher risk for the subsyndrome of agitation/aggression delusion in AD.",

keywords = "AGGRESSIVE-BEHAVIOR, Alzheimer disease, ApoE gene, BIOLOGICAL ASPECTS, CORTEX, E GENOTYPE, EPSILON-4 ALLELE, LATE-ONSET, LEWY BODIES, NEUROPSYCHIATRIC INVENTORY, NONCOGNITIVE SYMPTOMS, PSYCHOTIC SYMPTOMS, agitation, delusion",

author = "Cheng-Sheng Chen and Pei Ouyang and Yi-Chun Yeh and Chiou-Lian Lai and Ching-Kuan Liu and Cheng-Fang Yen and Chih-Hung Ko and Ju-Yu Yen and Gin-Chun Liu and Juo, {Suh-Hang Hank}",

year = "2012",

doi = "10.1097/WAD.0b013e31821f5787",

language = "American English",

volume = "26",

pages = "135--139",

journal = "ALZHEIMER DISEASE & ASSOCIATED DISORDERS",

issn = "0893-0341",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Apolipoprotein E Polymorphism and Behavioral and Psychological Symptoms of Dementia in Patients With Alzheimer Disease

AU - Chen, Cheng-Sheng

AU - Ouyang, Pei

AU - Yeh, Yi-Chun

AU - Lai, Chiou-Lian

AU - Liu, Ching-Kuan

AU - Yen, Cheng-Fang

AU - Ko, Chih-Hung

AU - Yen, Ju-Yu

AU - Liu, Gin-Chun

AU - Juo, Suh-Hang Hank

PY - 2012

Y1 - 2012

N2 - The aims of this study were to identify subsyndromes of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer disease (AD), and to investigate whether the apolipoprotein E (ApoE) gene confers a risk of distinct BPSD subsyndromes. BPSD of 96 patients with AD were assessed using the Neuropsychiatric Inventory. Factor analysis with principal component analysis and varimax rotation was used to construct the BPSD subsyndromes. ApoE genotypes were determined using the TaqMan technology. The results showed that the 5 subsyndromes can be determined, including: agitation/aggression-delusion, euphoria-disinhibition, depression-apathy, hallucination-nighttime behavior, and appetite. ApoE epsilon 4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome. We demonstrated that ApoE epsilon 4 confers a higher risk for the subsyndrome of agitation/aggression delusion in AD.

AB - The aims of this study were to identify subsyndromes of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer disease (AD), and to investigate whether the apolipoprotein E (ApoE) gene confers a risk of distinct BPSD subsyndromes. BPSD of 96 patients with AD were assessed using the Neuropsychiatric Inventory. Factor analysis with principal component analysis and varimax rotation was used to construct the BPSD subsyndromes. ApoE genotypes were determined using the TaqMan technology. The results showed that the 5 subsyndromes can be determined, including: agitation/aggression-delusion, euphoria-disinhibition, depression-apathy, hallucination-nighttime behavior, and appetite. ApoE epsilon 4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome. We demonstrated that ApoE epsilon 4 confers a higher risk for the subsyndrome of agitation/aggression delusion in AD.

KW - AGGRESSIVE-BEHAVIOR

KW - Alzheimer disease

KW - ApoE gene

KW - BIOLOGICAL ASPECTS

KW - CORTEX

KW - E GENOTYPE

KW - EPSILON-4 ALLELE

KW - LATE-ONSET

KW - LEWY BODIES

KW - NEUROPSYCHIATRIC INVENTORY

KW - NONCOGNITIVE SYMPTOMS

KW - PSYCHOTIC SYMPTOMS

KW - agitation

KW - delusion

U2 - 10.1097/WAD.0b013e31821f5787

DO - 10.1097/WAD.0b013e31821f5787

M3 - Journal Article

SN - 0893-0341

VL - 26

SP - 135

EP - 139

JO - ALZHEIMER DISEASE & ASSOCIATED DISORDERS

JF - ALZHEIMER DISEASE & ASSOCIATED DISORDERS

IS - 2

ER -

Apolipoprotein E Polymorphism and Behavioral and Psychological Symptoms of Dementia in Patients With Alzheimer Disease

Abstract

Keywords

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