Application of macroautoradiography and instantimage in radiopharmaceutical research

Jeng Jong Hwang; Tzu Chen Yen; Bor Tsung Hsieh; Gann Ting

doi:10.1007/BF02347216

Application of macroautoradiography and instantimage in radiopharmaceutical research

Jeng Jong Hwang, Tzu Chen Yen^*, Bor Tsung Hsieh, Gann Ting

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution of γ- and β-emitting radionuclides (^99mTc-MDP, ^99mTc-sulfur colloid, or ¹⁸⁸Re-HEDP), and results obtained from both methods were compared. The biodistribution of ^99mTc-MDP and ¹⁸⁸Re-HEDP were seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The ^99mTc- sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of Packard Instantimager. However, the advantage of Packard Instantimager is that rapid imaging within few minutes is possible with it, while WBAR imaging requires several hours to days.

Original language	English
Pages (from-to)	581-587
Number of pages	7
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	241
Issue number	3
DOIs	https://doi.org/10.1007/BF02347216
State	Published - 1999
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF02347216

Cite this

@article{67cf6e3aace14b74a72f20b01dabca19,

title = "Application of macroautoradiography and instantimage in radiopharmaceutical research",

abstract = "The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution of γ- and β-emitting radionuclides (99mTc-MDP, 99mTc-sulfur colloid, or 188Re-HEDP), and results obtained from both methods were compared. The biodistribution of 99mTc-MDP and 188Re-HEDP were seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The 99mTc- sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of Packard Instantimager. However, the advantage of Packard Instantimager is that rapid imaging within few minutes is possible with it, while WBAR imaging requires several hours to days.",

author = "Hwang, {Jeng Jong} and Yen, {Tzu Chen} and Hsieh, {Bor Tsung} and Gann Ting",

year = "1999",

doi = "10.1007/BF02347216",

language = "英语",

volume = "241",

pages = "581--587",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Akademiai Kiado ZRt.",

number = "3",

}

TY - JOUR

T1 - Application of macroautoradiography and instantimage in radiopharmaceutical research

AU - Hwang, Jeng Jong

AU - Yen, Tzu Chen

AU - Hsieh, Bor Tsung

AU - Ting, Gann

PY - 1999

Y1 - 1999

N2 - The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution of γ- and β-emitting radionuclides (99mTc-MDP, 99mTc-sulfur colloid, or 188Re-HEDP), and results obtained from both methods were compared. The biodistribution of 99mTc-MDP and 188Re-HEDP were seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The 99mTc- sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of Packard Instantimager. However, the advantage of Packard Instantimager is that rapid imaging within few minutes is possible with it, while WBAR imaging requires several hours to days.

AB - The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution of γ- and β-emitting radionuclides (99mTc-MDP, 99mTc-sulfur colloid, or 188Re-HEDP), and results obtained from both methods were compared. The biodistribution of 99mTc-MDP and 188Re-HEDP were seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The 99mTc- sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of Packard Instantimager. However, the advantage of Packard Instantimager is that rapid imaging within few minutes is possible with it, while WBAR imaging requires several hours to days.

UR - http://www.scopus.com/inward/record.url?scp=0032873664&partnerID=8YFLogxK

U2 - 10.1007/BF02347216

DO - 10.1007/BF02347216

M3 - 文章

AN - SCOPUS:0032873664

SN - 0236-5731

VL - 241

SP - 581

EP - 587

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 3

ER -

Application of macroautoradiography and instantimage in radiopharmaceutical research

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this