Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Shu Leei Tey, Chi Ying Li, Li Wei Lin, Li Ching Chang, Yea Ling Chen, Fang Rong Chang, San Nan Yang, Ching Chung Tsai*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations


Background: Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility. Methods: We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES. Results: The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES. Conclusion: A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.

Original languageEnglish
Article number275
JournalBMC Complementary Medicine and Therapies
Issue number1
StatePublished - 12 2021
Externally publishedYes

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  • Arecae pericarpium
  • Lower esophageal sphincter
  • Motility
  • Muscarinic receptor


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