Arterial spin-labeling perfusion imaging of childhood meningitis: a case series

Alex Mun Ching Wong, Chih Hua Yeh, Ho Ling Liu, Kuang Lin Lin, Huei Shyong Wang, Cheng Hong Toh*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations


Introduction: Conventional magnetic resonance imaging (MRI), which is mainly used to detect complications, is ineffective in determining the neurological status of patients with meningitis. Hemodynamic change in the brain may be more indicative of the neurological status but few imaging studies have verified this. Arterial spin-labeling (ASL) perfusion, a noninvasive MR method requiring no contrast agent injection, can be used to measure cerebral blood flow (CBF). Case reports: We describe three pediatric patients with meningitis, who all showed regions of increased CBF on perfusion imaging. One patient, presenting with headache and conscious disturbance, had CBF changes in the frontal, temporal, and occipital regions. The other two patients, presenting with hallucinations, memory deficits, and seizures, had CBF changes in the frontal and temporal regions. Conclusion: ASL perfusion imaging may be helpful in assessing patients with meningitis, demonstrating CBF changes more strongly correlating with the neurological status, and detecting active brain abnormalities.

Original languageEnglish
Pages (from-to)563-567
Number of pages5
JournalChild's Nervous System
Issue number3
StatePublished - 01 03 2016

Bibliographical note

Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.


  • Arterial spin-labeling perfusion
  • Cerebral blood flow
  • Meningitis


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