Asian pacific association for the study of the liver consensus recommendations on hepatocellular carcinoma

Masao Omata*, Laurentius A. Lesmana, Ryosuke Tateishi, Pei Jer Chen, Shi Ming Lin, Haruhiko Yoshida, Masatoshi Kudo, Jeong Min Lee, Byung Ihn Choi, Ronnie T.P. Poon, Shuichiro Shiina, Ann Lii Cheng, Ji Dong Jia, Shuntaro Obi, Kwang Hyub Han, Wasim Jafri, Pierce Chow, Seng Gee Lim, Yogesh K. Chawla, Unggul BudihusodoRino A. Gani, C. Rinaldi Lesmana, Terawan Agus Putranto, Yun Fan Liaw, Shiv Kumar Sarin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

891 Scopus citations


Introduction: The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods: The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. Results: Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

Original languageEnglish
Pages (from-to)439-474
Number of pages36
JournalHepatology International
Issue number2
StatePublished - 06 2010
Externally publishedYes


  • Consensus statements
  • Diagnosis
  • Epidemiology
  • Hepatocellular carcinoma
  • Recommendations
  • Treatment algorithm


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